Microbes vs. Maladies

Dr. A. Robert Franco’s website for the Arthritis Center of Riverside tabulates many of the relationships between microbes and rheumatic conditions. 


 Inflammation-associated microbial colonies can be of many species, but specific bacteria are associated with certain conditions and organ tissue/cell targets, because the microbes have attachment molecules that fit specific cell receptors.  Many microbes (bacteria, viruses, yeasts, fungal forms, L-forms, Mycoplasma, etc.) do, as part of their life cycle, invade and colonize host cells, disrupting cell chemistry without killing the cell. [Reference: veterinary science conference presentation: Infectious Causes of Anaemia].


Some well known microbial factor/co-factors of chronic maladies:


Disease / Condition

Microbial Factor/Co-factor


Helicobacter pylori, yeast, hyperglycemia. Diabetes leads to immune suppression

Sinus infection, Rheumatoid Arthritis

Streptococcus pneumonia, L-Form is Mycoplasma-like

Pneumonia, Rheumatoid Arthritis

Mycoplasma pneumoniae,

 M. fermentans, M. penetrans

Malaria (mosquito-borne)

Plasmodium falciparum colonizes liver cells and red blood cells

Necrotizing Fasciitis: microbe-produced enzymes rapidly dissolve muscles and tissues

Human Herpes Virus-6 (HHV-6) combined with Group A Streptococcus aka “scarlet fever”

Heart disease, walking pneumonia

Chlamydia pneumoniae, plaques, scarring; >50% human reservoir

Alzheimer's, atherosclerosis

Chlamydia pneumoniae, plaques, scarring, Lyme = Bb spirochetes penetrate blood-brain boundary permitting other pathogens entry

Parkinson’s tremor:  too-low levels of L-dopamine inhibit nerve action of brain transmitter cells controlling muscles. Oxides produced by brain infection and inflammation kill cells that produce L-dopamine.

Nocardia asteroids, which is sensitive to minocycline or combined ampicillin and erythromycin augmented by large doses of antioxidants (vitamins C, E, A).

Multiple Sclerosis: nerve myelin sheaths are dissolved via enzymes and inflammation


Lyme Disease

Borrelia burgdorferi, Borrelia lonestari, colonize red blood cells. These spirochetes destroy  the blood brain barrier, allowing other microbes to invade and infect the brain

Ehrlichiosis  (tick-borne)

Ehrlichia chaffeensis invades white blood cells

Diabetes, Type I

Coxsackie virus and/or congenital Rubella

Crohn's Disease from dairy products

Mycobacterium paratuberculosis

(Johne's Disease) cattle >20% infected

M. paratuberculosis is heat resistant

Lower spine disintegration, inflammation, reactive arthritis, Ankylosing Spondylitis

Gut infections: HLA-B27 cross-reacts with antigens found in Klebsiella, Salmonella, Shigella and Yersinia micro-organisms

Irritable Bowel Syndrome (IBS) and Crohn’s inflammation

Candida albicans, yeast, tubules, colonizes cells, perforates gut/blood membrane

Fibromyalgia-like, Hashimoto’s hypothyroiditis

Immune cells attack thyroid cells; an unknown virus is suspected, possibly Coxsackie



Disease Testing and Treatment:


Caution: Not all labs insist on the freezing of submitted samples, resulting in excess test errors.

·        An online reference on infections and testing is Infectious Disease: Use & Interpretation of Laboratory Tests  by Dr James Peter at Specialty Laboratories, Valencia, CA. This lab performs Marshall Protocol-related testing.

·        An excellent disease therapy reference is Pocket Book of Infectious Disease Therapy by John G Bartlett, Williams & Wilkins Publisher, 1996.

·         Quest Diagnostics Laboratories performs Marshall Protocol-related testing. Their website lists Service Centers.


Conventional testing for bacteria usually fails


In most cases the colonizing microbes’ larger forms are not detectable or even present in the blood or at inflammation sites. It is easier to detect the generated enzymes and molecules than the cloaked microbe.  However, in many cases certain microbe-specific antibodies may be present, indicating past exposure, confirming the likelihood of colonization. When many of the infected macrophages die, the smaller forms may attempt to revert to the larger form and they may become detectable. They are too slow-growing to be effectively cultured in a short time frame and in vitro (laboratory-generated) culture mediums do not exist for the intracellular forms.


Bacterial forms include Cell Wall form, Cell Wall Deficient (CWD) form, intracellular form, cyst/bleb dormant form (hibernating). The dormant form is resistant to antibiotics. Effective antibiotic treatment needs to address each form either concurrently or in alternation. Pulsing the antibiotics can trick the dormant forms into emerging and they become vulnerable to antibiotics after they start up their metabolic processes. Many microbial strains depend on sugar (fructose, glucose, sucrose, etc) in their metabolism, hence greatly reducing sugar intake for all types of sugars for an extended period may break the reproductive link of many bacterial/fungal strains.


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