Ongoing Research (2002 – Present)

Koch's Postulates: We should not let their simplicity restrict our thinking: (Oct 2011)

A doctor would not listen to a patient and cited Koch’s postulates as the reason the patient was mistaken. Actually, the patient, not the doctor, was more informed.

Nature gives us many counterexamples to Koch’s method of linking a single microbe to a disease or condition. There are many problems with Koch’s 19^th century simple rules. Many pathogenic microbes are persistent. The bacteria are polymorphic---changing their forms. The invaders live part of their lives inside our cells. The target multiple cell-types include immune cells and epithelial cells everywhere in the body.

The invaded target cells make disrupting bioactive molecules and stop making others. To understand chronic disease we need to understand each of the many immune-stimulation cofactors, not just one. We find multiple-microbe-complexes (biofilm & plaque colonies) associated with COPD, Rheumatoid Arthritis, IBS, CFIDS, Fibromyalgia, Heart/Artery Disease, Brain Plaques, Cancer, etc.

Polymorphic microbe complexes require multiple antibiotic types plus other modes of medical attack. Koch’s postulates represent a compelling intellectual simplicity: one bug = one disease = one medicine. This kind of thinking is inadequate to characterize the complex natural world.

Arguing From Minimized Statistics Leads to Problems (January 2012)

Arguing from a small number and extrapolating to a large set of different cases is problematic. In Logic, if you argue from the empty set you can prove anything. Anything is true if it applies to nobody. The politician that keeps none of his promises can logically promise the electors the world plus anything beyond their wildest dreams.

Invalid logic and minimized data is used to fool us that authorities and administrators are operating properly. Bad data plus bad statistics leads to bad management and bad medicine, with no corrective actions.

Our statistics are minimized by neglect, by fear-to-report, by losing the data, by prejudicial inhibitions, by event miss-categorization, by defining too restrictive criteria, and by using poor tests with many false negatives. Omission is not the “whole truth”. Omission causes us to avoid facing the important issues and to fail to fund critical solutions.

Natural Antiviral Foods, Herbs, Oils (Oct 2011)

There are very few antiviral medicines. However many natural foods (rarely eaten), herbs, and oils have antiviral, antibacterial, antifungal, and anti worm properties. Here is a starter list for your web searches into the properties of these natural medicines obtained from plants.

Clinic at WalMart: Low Cost Medical and Drugs Access (January 2012)

WalMart is positioning a physician staff at its in-store “Clinic at WalMart” to permit walk in medical services, injections, and immediate access to their low cost ($4/30day $10/90day supply) formulary of ethical drugs. WalMart has the global reach to buy world wide, from low production cost sources, providing world class quality pharmaceuticals. They operate a cash business, but also take insurance at their more than 140 clinics nationwide. They buy prepackaged drugs from Canada, India, and other centers of production excellence. This business model eliminates much of the overhead from pill counting, insurance, delayed billing and accounting. Clinics are independently owned. Locations

Nutrition, Orthomolecular and Alternative/Complementary Medicine (Dec 2011)

· National Library of Medicine Complementary Medicine

· Linus Pauling Institute @ Oregon State University

· Journal of Orthomolecular Medicine

· Mary Enig’s Fats/Oils Papers: Google[enig coconut antiviral]

· Klenner and Cathcart References

Statins Interfere with Cholesterol Functions and CoQ10 Production (Nov 2011)

Statin drugs block manufacture of CoQ10, an essential nutrient. Statins block cholesterol generation, cause muscle pain and atrophy, cause systemic cellular mitochondrial dysfunctions, and neuropathies. If statins are taken, high levels of ascorbic acid (AA) and CoQ10 should also be taken. There are many adverse symptoms of statin intake without adequate dietary supplementation. Statins accelerate the deterioration we call ageing.

Statins are prescribed in the mistaken belief that cholesterol causes arterial plaques and heart disease. The synthesis of essential CoQ10 and Heme are also blocked. Cholesterol starvation, low CoQ10 and Heme in the presence of oxidation-stress causes muscle and nerve atrophy by induced mitochondrial energy dysfunction, oxidized toxic cholesterol. Cholesterol starvation causes the failure to regenerate cells as they die off. Adverse drug reactions to statins are underreported, compared to the reports collected by websites that independently report harm to statin taking patients.

Cancer vs. Microbes Table with References to Medical WikiPedia (Dec 2011)

Microbes are associated with many Cancers. SV-40 Simian Virus 40 was a contaminant in live Polio vaccine. It shows up in the table in many places as a Cancer-associated infection. Other infections are also found to increase the probability of certain Cancers. This table has links to the medical articles in WikiPedia to make it easy to look up the supporting data.

Diseases/Conditions Vs. Microbes: Table with References to Medical WikiPedia (Dec 2011)

Chronic infections by Viruses, Bacteria, and some fungus/yeasts are linked to specific diseases and conditions. The members of the Hepatitis and Herpes virus groups are multiply associated elements. Another repeated co-infections are in the insect borne Borrelia species. Others are RSV, EBV, CMV, VZV, Mycoplasmas and the ubiquitous Chlamydia pneumonia. This table has links to the medical articles in WikiPedia to make it easy to look up the supporting data.

Urinary Tract Infections: Mycoplasmas and Ureaplasmas (December 2011)

From the Road Back Foundation Website Antibiotic Protocols

The names of the Mycoplasmas found in UTIs and other body locations as colonies. The table shows the number of strains of each mycoplasma their antibiotic susceptibilities and resistant-to antibiotics. Susceptibilities are not quantified in this table. Later data of this kind may be found on the internet or in drug reference sources.

Why Doctors Might Not Use the Brown Antibiotic Protocol (January 2012)

For various reasons doctors may prefer to use only anti-inflammatory treatments without the antimicrobial antibiotics. This page contains the reasons why.

Ketonic AA Antibiotic Protocol with Nutrition Factors (January 2012)

Ketosis plus vitamin C  (AA) is an adjuvant to the Tetracycline-antibiotic protocol. Combine Klenner's AA and Rheumatoid Arthritis The Infection Connection, Appendix 2: Tetracycline/Minocycline Protocol. Benign ketosis is induced by drastic reduction of carbohydrate intake to ~ 15 grams of carbohydrates per day. [See Dr. Atkins’ diet induction stage]

The liver shifts from fat storage mode to fat extraction mode and brown fats are catabolized to acetyl CoA to feed the Krebs (citric acid) cycle where ATP is made to feed energy to all the body cells. Body-cell sugar use shuts down. Hypo-glycemic condition stops in ketosis mode. HDL/LDL lipid levels normalize.

Microbes and viruses are sugar dependent, so are drastically starved. ROS of the chronic infection oxidizes the AA to the Dehydro AA (oxidizing) form. Microbes, microbe-infected body and cancer cells need sugar and cells ingest oxidized Dehydro Ascorbic Acid (DHA) instead of sugar.  Inside the microbes and the infected cells the DHA oxidizes the cells' mitochondria and induces apoptosis (cell death). Full Details:

Gut Bacteria and Health Countermeasures (Nov 2011)

Microbes in the gut work to make food more useful. Bad microbe strains can lead to dysbiosis. Antibiotics make the gut unbalanced. Here is a list of problem microbes along with pointers to ways you can easily reboot your gut flora and maintain a healthy balance.

Metallo Enzymes a Complex of Active Molecules (Jan 2012)

Antibiotics and Zinc supplements have complex roles in antimicrobial defenses. Knowing what and how enzymes containing certain metal atoms function to perfect and control our immune system is a fertile field of investigation at this time. Here is an overview with some practical surprises using nutritional quick fixes.

Gut Bacteria Metabolic Syndrome, Heart Disease and Lecithin (Dec 2011)

A Common bacteria (L. rhamnosus) in mice with guts repopulated with human microflora makes fishy smelling gas, TMA, that the liver converts to TMAO and HDL cholesterol. Atherosclerotic plaques grow faster. Change gut flora with antibiotics and the TMA production stops. Lecithin has choline which is a neural nutrient. This is a surprising new result: high levels of lecithin as a supplement are to be avoided. Gut microflora appear to be at the root of metabolic syndrome and obesity.

Microbe gene mapping is linked to molecule making data for probiotics. This enables a systematic way to catalog and predict the way specific gut microbes control human biochemical processes.

This concise note contains a treasury of recent Pub Med Abstracts and links to additional online references for the serious student.

Vaccines Plus Mitochondrial Dysfunction Cause ASD: A Revolution in the Vaccine Court (Nov 2011)

HHS has admitted liability for ASD symptoms and harm in the Hanna Poling case. They admitted that vaccines plus genetic mitochondrial dysfunction (MD) causes ASD disabilities. HHS now has a big problem.

The assumed rarity if MD is an illusion. Statins cause MD. Scurvy causes MD. Malnutrition plus persistent microbial chronic infections cause MD.

By the rules of the court, many vaccine-caused slow to emerge ASD cases will be excluded. Still, a lot of cases will be settled in plaintiff family’s favor. The average claim is a little less than $ 1 Million. Family lifetime cost is estimated at $3 million. The autism incidence rate is now about 1/100, and still getting worse.

If every ASD diagnosis led to a claim, the paid in premium for a ~$1 Million claim would be $225. If the fund were to break even, the claims rate should be less than ~3/10⁶. If the number of outstanding ASD claims were 10,000, claims would be ~$10 billion.

This is HHS’ big problem: The fund does not collect enough cash thru the tax to cover the harms that will be linked to the problem vaccinations.

Legislation now exists to raid the compensation fund “surplus” to offset budget shortfalls, and new programs.

But there is actually a huge potential liability that wipes out the surplus. The discussion at the above link shows functionally just how vaccines can and do cause the vaccine associated injuries that we see in practice.

Adjuvant Persistence Causes Chronic Autoimmune Syndrome (Jan 2012)

The first reference is an analysis of the toxicity of aluminum oxide adjuvants in vaccines. Both the cumulative toxicity and the persistence of the adjuvant in injection site muscles has been underestimated. Evidence from an increasing number immunology experts prove that vaccine caused immune hyperactivity becomes chronic. Causality is denied as a mystery by the controlling authorities, The causes are obviously related to a fundamental active component in the vaccines, the adjuvant, aluminum oxide. It would be embarrassing to do a safety reassessment, so years pass by without one.

· Cumulative Aluminum Toxicity in Pediatric and Military Vaccines

The next reference gives the proof that the adjuvant stays around at the injection site and causes iatrogenically-caused functional muscular dystrophy. Treatment might be chelation and massage to remove the toxic residues in the injection site muscles.

· Macrophagic myofasciitis Lesions Long-term persistence of vaccine-derived aluminum hydroxide in muscle

Vaccines Vs. Scurvy Notes: Kalokerinos related URLS (Dec 2011)

www.whale.to has a body of vaccine related inputs from patients and doctors around the world. Archie Kalokerinos first described the mass deaths in Australia of scorbic natives soon after vaccination. He continued to point out that Sudden Infant Death Syndrome (SIDS) and Shaken Baby Syndrome (SBS) are caused by sudden onset scurvy and associated shock.

The global health machine has and continues to suppress the knowledge of vaccines harms in the presence of scurvy. The result is that later in Africa, the whole pattern of vaccine caused deaths repeated.

In the developed world, where vaccines are being used more and more, ASD prevalence has increased from ~1/10⁴ to ~1/10².

The danger of childhood illnesses is overstated. The anti-viral properties vitamins A and C as well as the saturated, palm-derived oils, Lauric and Palmitic acids is not well appreciated.

With proper nutrition, much of the need for antiviral vaccines would not exist. Without the same nutrition, the vaccines themselves are causing harm.

These notes are for the serious student who wishes to explore the global knowledge and opinion about Vaccines, Nutrition, and Scurvy.

Heart Disease And Fat Nutrition: An Anecdotal Rant (Nov 2001)

The cause of Heart Disease is microbial, Cpn, Bb, and others. We are playing worthless HDL/LDL statistical games at great expense and human cost. That approach is truly a mirage created to sell statins.

Statins are proving to be harmful and life shortening. Essential CoQ10 production in the mevalonate pathway in the liver is blocked. Essential dietary fats starvation and cholesterol starvation are pathogenic in the face of chronic infections, ROS and scurvy.

AA deficiency is endemic and is highly dynamic. We need to change direction on heart disease treatment. Kill the bugs.

Start eating vitamin C as an essential food that is metabolized and needs replacement at every meal. We should eat tropical saturated oils, especially essential Lauric acid, which is a “good-cholesterol” and hormone precursor as well as a potent antimicrobial food.

We need to stop taking statins which block our making of CoQ10, Heme, cholesterol and other essential metabolic molecules. If we persist in prescribing statins, we need to prescribe high levels of CoQ10 daily. We also should take more CoQ10 when we have low energy symptoms, mitochondrial dysfunction, or get older than age 40.

A Revolution in Our Understanding of Oils and Nutrition: (Nov 2011)

Elimination of essential tropical oil precursors in our diet is contributing to gut, blood, lymph and respiratory dysbiosis. Lauric acid (LA) in coconut oil converts to monolaurin (ML) in the gut. ML dissolves microbe’s lipid coatings and interferes with their ability to bind to target cells.

A palm oil derivative, Palmitoyl-oleoyl-phosphatidyl-glycerol (POPG), a phospholipid surfactant, is normally found in the lungs. It plays a complex beneficial role in binding to respiratory synclinal virus (RSV), to Mycoplasma pneumoniae, and likely to other COPD bacterial components.

Microbes inactivated by these diet lipids include a wide range of viruses, bacteria, yeasts, and protozoa.

A huge worldwide body of reports on the use of vitamin C (ascorbic acid = AA) is accessible on the internet. Accounting for its pharmacokinetics, pharmacodynamics, and safety, it can now be used dependably as a drug in appropriate concentrations, orally, by injection or by IV. Dr. Klenner reports on using oral AA to stop the measles virus, and to kill it with higher sustained oral inputs.

Kefir Probiotics: (Nov 2011)

Buttermilk, yogurt, doogh, and Kefir are natural fermentations of milk’s lactic acid. Kefir is a standard commercial product that is usually flavored. Kefir is consumed to provide fresh probiotic cultures for re-populating the gut microflora. This article lists the various bacteria and one yeast culture that have been found to exclude pathogenic bacteria. Beneficial microflora strains are defined with their benefits.

Vitamin C (Ascorbic Acid) IV Treatment Protocols for Cancer (Oct 2011)

Tumors consume large amounts of Ascorbic Acid (AA). They deplete the AA supply for the rest of the body, causing scurvy-related illnesses, leading to death. The amount of AA needed in case of cancer and infection can be huge, in the range of tens to hundreds of grams per day. Supplying large amounts (1gram-AA/Kg of body weight) by IV can exceed the tumor-cell killing level of AA in the blood. AA in these high concentrations is not harmful to normal cells. The AA in the oxygen starved cancer cell converts to an oxidizing form (dehydroascorbic acid) that kills the cell. IV AA is an antiviral, antibacterial, antifungal, antitoxin, antishock, and antagonist to immune-cell-invading pleomorphic microbes. For the serious student: listed AA-associated URLs point to a large number of serious articles about AA, its history, its chemistry, its biological activity, and its successful use as an alternative therapy.

PubMed: Ascorbic Acid: Anti-Tumor, Anti-Angiogenic, PharmacoKinetics: (Nov 2011)

Dosage from DoctorYourself.com. Three abstracts establishing that:

· AA anti-tumor properties are from oxidizing-form of AA, not anti-oxide form. Hydrogen peroxide = H₂0₂ mechanism.

· AA anti-angiogenic action is via H₂O₂ mechanism. Angiogenic means stimulating growth of new blood vessels.

· The ½ hour AA blood concentration half-life needs to be taken account in dosage and AA administration.

· One-shot, low-dose experiments prove only that absence of AA is not a remedy. ½ hour half-life.

· Disregard of the very short AA half-life invalidates all experiments showing “no AA effects on diseases.”

· Where AA blood concentration was unmonitored, AA may be presumed to be essentially absent.

· Using proper pharmacokinetics, high enough AA dosages (by IV) will have predictable positive effects in vitro.

· Klenner and Cathcart’s methods are in accord with current AA pharmacokinetics knowledge.

· Klenner and Cathcart’s reports have been validated by reports from around the world, where they were consistent with their methods and AA pharmacokinetics as now known.

· We need to properly perform AA clinical studies with AA blood levels above those proven effective in vitro.

· In animal experiments, if AA is used as a treatment, AA blood concentration must be maintained and or measured, not discontinued in the middle of the trial.

Vitamin C PharmacoKinetics and PharmacoDynamics: (Nov 2011)

Vitamin C (Ascorbic Acid) is an essential wonder-food. It protects us from stress, from microbes, and can be rapidly depleted when we are sick. It is water-soluble; its blood half life was measured at ½ hour.

· How AA really works and How to make it work dependably

· Here is what it means to you, so you can improve your health.

COPD, ASD, & Infections: Diet Countermeasures (Oct 2011)

Outdated diet propaganda contributes to our malnutrition. Tropical oils and vitamin C can suppress/kill viral/microbial gut and respiratory infections. MMR live mumps virus can colonize the gut. Coconut and palm oils dissolve lipid viral coatings and block viral actions. Vitamin C in high persistent levels acts as an antibiotic. ASD may have a MMR live vaccine measles gut chronic infection component. COPD has RSV, Mycoplasma pneumonia, Chlamydia pneumonia, and other viral/bacterial components. Diet changes may improve your immunity and suppress the infections.

A table of antibiotics targeting COPD bacteria. Pneumonic bacteria—Mycoplasma Pneumonia, Streptococcus Pneumonia, Chlamydia pneumonia, and many more start their invasion in as a respiratory infection and then move to infect epithelial cells and other cells in the Respiratory and Intestinal tracts and other parts of the body. When they invade synovial epithelial cells they cause arthritis, atherosclerosis, IBS, UTIs, and heart disease.

Link to: Mycoplasma Photomicrographs From MicrobeWiki.Kenyon.edu

Mycoplasma strains seen using darkfield microscopy (1000x).

Link to: CWD L-Forms History A stellar web article…at Bacteriality.com

A History of Cell Wall Deficient Bacteria: A Selection of Researchers Who Have Worked with the L-form Author: Amy Proal

Link to: Lyme Disease Borrelia Burgdorferi Information and Pictures

60,000 understated estimated infections per year. Testing and treatment is largely ineffective, leading to spirochete caused dementia similar to syphilis in millions of persons. Mosquitos have caused a bird imported rise in B.b microbiome infections in ticks from 4% to 40% in a period of only 10 years. Nationwide this is a huge health problem increasing costs for Medicare in the later years of life.

@ LymeFacts.webs.com: Chronic Lyme Disease is caused by extreme microbial persistence. Our testing and treating methodology is so incomplete that we do not know enough to scope, much less to solve the problem. It is the Uni-dimensional blind men viewing the multi-dimensional elephant all over again, except the discourse has been far from collegial between those who have to treat and the scientists.

“B. burgdorferi has been shown to invade a variety of cells, including endothelium, fibroblasts, lymphocytes, macrophages, keratinocytes, and synovium. By 'hiding' inside these cells, B. burgdorferi is able to evade the immune system and is protected to varying degrees against antibiotics, allowing the infection to persist in a chronic state.” See Ketonic Protocols

Endowment 4 Med Research 2006 Lyme Update From PDF: Lyme causes symptoms misdiagnosed as: ADD/ADhD, Autism, Juvenile Arthritis, Rheumatoid Arthritis, Reactive Arthritis, Infectious Arthritis, Osteoarthritis, Fibromyalgia, Raynaud's Syndrome, Chronic Fatigue Syndrome, Interstitial Cystis, Gastroesophageal Reflux Disease, Fifth Disease, Multiple Sclerosis, scleroderma, lupus, early ALS, early Alzheimer’s, crohn's disease, ménières syndrome, sjogren's syndrome, irritable bowel syndrome, colitis, prostatitis, psychiatric disorders, bipolar, depression, encephalitis, sleep disorders, thyroid disease to mention a few of 350 diseases that could possibly be Lyme.

· Colorful Lyme Lecture by Alan McDonald, a pathologist, 2007

· A life cycle for Borrelia spirochetes.htm

· Lyme spirochetes Pictures linking syphilis and Lyme spirochete CWD L-forms

· LYME DISEASE (Borreliosis) A Plague of Ignorance Regarding the Ignorance of a Plague© 2004, Dr Scott Taylor, DVM, All rights Reserved

· Tick Microbiome Only a small geographic sample Other complicating co-infections include HSV2 see

· LymeDiseaseResource.com/ Jenna’s Lyme Blog Articles

• Syphilis: The Ugly Cousin
• Ivermectin for Chronic Lyme? I give that to my horse!
• New Biofilm Busting Protocols For Chronic Lyme Disease
• Dr. Burgdorfer Explains Existence Of Chronic Lyme Disease And Similarity To Syphilis
• Lyme Disease On The Rise – Sexual Transmission?
• Is Lyme Disease Transmitted Sexually?
• The Horrors of Herxheimer
• Lyme Boost – Moose Dying In Maine from Ticks
• Why Can’t We Recover From Lyme Disease?

· New Treatment for Lingering Neuropathic Pain

Inflammation in RA, Fibromyalgia, and Sarcoidosis

Latent intracellular macrophage colonies have been shown to be an important causal factor in several chronic autoimmune disorders. Macrophages normally eat invaders and allergenic proteins. Some microbes invade and colonize macrophages, taking over their DNA, using the cells to make toxins, allergens and enzymes, upsetting the body’s molecular equilibriums. This imbalance leads to autoimmune conditions such as RA, Fibromyalgia, and Sarcoidosis. The Marshall Protocol is a successful approach to treatment of Scarcoidosis, which resembles Fibromyalgia.

Chlamydia pneumoniae Linked to Heart Disease, Stroke, and Alzheimer’s

Persistent and slow-growing C. pneumoniae infections lead to a variety of circulation-related disorders. Symptoms do not appear for years, while the infection deposits arterial plaques that lead to heart attacks and strokes. Autopsies of heart attack victims showed 60% were infected with previously undetected C. pneumoniae.

How Yeast Infection Aggravates Rheumatic Symptoms

Rheumatoid Arthritis, Fibromyalgia, hypothyroidism and other ailments characterized by inflammation, joint pain, and chronic fatigue are made worse by an overgrowth of Candida albicans. Fortunately, the Candida organism can be reduced and controlled, largely through dietary adjustments.

Microbes Vs. Maladies

Many parasitic microorganisms (bacteria, viruses, yeasts, fungal forms, L-forms, Mycoplasma, etc.) are able to invade and colonize host cells, disrupting cell chemistry without killing the host cell. This article presents a table of microbial co-factors and their role in well-known medical conditions.

Conditions

A list of conditions benefiting from antibiotic (Minocycline, etc) protocols.

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