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A Single RDA Is Not For Everybody; Upper safe limit is bogus
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Contradictory Data
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Tolerable Upper Limit Also Flawed
What the ½ hour blood half-lifetime means Vitamin C Calamity
AA Pharmacokinetics (Pk) is what
the body does to the drug; pharmacodynamics
(Pd) is how the drug effects the body and its target organs, biological functions,
chemical processes and/or microbes and parasites.
AA Pk deals with how it is administered effectively
in what form, amounts and frequencies.
AA is in foods, more in certain sources.
AA is supplemented by oral uptake in the gut, by injection and via IV
infusions directly into the blood. Oral intake has many forms (AA, sodium
ascorbate, calcium ascorbate, magnesium ascorbate, and ascorbyl palmitate), the
most effective gut-to-blood uptake is Liposomal AA where ~95% is transferred
vs. less than 15% for water-soluble forms of AA. Pk deals with rates of change in
concentration: how & where & how much & how fast it is distributed,
stored, converted, metabolized and eliminated.
It
is an essential molecule used in countless vital chemical pathways.
Many experiments and conclusions about vitamin C (AA) have not taken account of the high reaction rates, short store-away times, and excretion/depletion rates of this highly reactive molecule. It is like trying to put a tiny amount of water in a bucket with a large hole in the bottom a little bit each day and measuring the effect over days months or years. Most of the time the bucket is empty, AA is depleted, but we have been thinking we are measuring what we put in.
One rat experiment with pneumonia proved that AA kept the rat alive with frequent low doses and concluded that AA was worthless, because when AA was stopped, the rat died. Rats make AA, (humans do not) but rats did not make enough AA to stop this particular tough bug. What ethical doctor would deny a medicine (or food) that works for a patient and stop giving it because he knew that on stopping the patient is sure to die. Most likely if it helped he would give more, like Dr Klenner did and found that it killed all the viruses if the dosage was high enough in the therapeutic range and administered 24/7 at effective concentrations. The important conclusion: there is no unsafe upper limit for AA. Only unsafe too-low administration amounts when the patient is in crisis.
Some physiologies include dependencies, like dependency on food. If we mistakenly call a food a “vitamin” and we ration food like vitamins with low RDAs, should we be surprised that the patients will starve?
So it is with Scurvy and Life extension. See Ely(7) and the related pictures showing age regression with adequate high levels of AA, CoQ10, and Lysine. AA starvation shows up as premature aging. Statins induce scurvy; they increase the rate of aging. Part of the aging is reversible, given a similar diet to Ely’s.
On taking AA I notice in about 15 minutes the
increase of the pressure in my eyes’ lenses, where AA is stored, as the focus
snaps into clarity from the depleted blurred state. When fighting illness the reaction or
depletion times are about ½ hour to diminish symptoms to about 3 hours til
their return. Who in practice measures
blood AA every few minutes? Who measures
the AA/DHA ratio as an indicator of biochemical vitality? They should, it is a
wonderful criticality-measure, predictive of end state lifetime. Make the ratio better, and mortality and
morbidity are greatly reduced. Patient
comfort is improved in many ways.
What is important is AA in the tissues where it is stored and depleted from. This too is dynamic. Study the course of Marburg to see how fast the reactions can take. This is scurvy as fast as it works. Scurvy can act slowly too, over months to years. It depends on our ROS/NOS levels, which increase with age and infection load. Venoms work by depleting AA rapidly.
So experiments similar to a hypothetical ten year,
200,000 healthy patients, less than one gram per day studies are like covering
a large rock with paint so thin that it does not cover the whole rock, only a
part of it for a molecule thick and lasting only a few minutes per day, until
the paint coverage evaporates away. No wonder that the effectiveness of AA is
like a no-se-eum.
Later we will see a FDA AA
Studies collection of partly flawed long-term AA experiments. It is
hard work to see the flaws but the inconsistencies need resolving on the
functional chemistry level. Scurvy is a
slow AA depletion in a healthy person. Rapid onset scurvy (anascorbemia) is
rapid oxidation of AA to DHA. In both cases the antioxidant AA goes critically
low.
The challenge to science today is to rethink the
entire body of evidence in all the AA Historical Archive
AA Papers and AA effectiveness, disproving experiments and to
revalidate/disprove parts of all of them. Re-considering the AA molecular
dynamics that have been reported and can be measured. AA’s oxidation rates are high, it is
metabolized within minutes, it changes from active AA(reducing) to
DHA(oxidizing) instantly.
When AA is oxidized it loses two electrons, it can
no longer donate electrons to chemical pathway processes. The electron orbital
paths of DHA shift-around into a different shape than for AA. When oxidized, the AA molecule changes shape.
DHA no longer fits into other molecules in the same way as AA; DHA interacts differently;
and vital chemical reactions, all that depend on AA, just stop reacting and
changing. All vital AA-dependent reactions stop or slow at the same time. This
is so similar to anaphylaxis it may be the same. AA instantly reverses
anaphylaxis. Adrenaline causes the one-time release of about 5 grams of AA.
When AA is converted to DHA the AA/DHA ratio shifts towards 1 and below, the AA in the blood goes below the critical level and histamine release explodes exponentially. Blood vessels start to leak and systemic bleeding starts nearly everywhere, brain, eyes, lungs, kidneys … all hemorrhage, especially in the gut where you see tarry stools. Just study the hemorrhagic fevers pathologies. These are the classic pathologies of end-state scurvy, in the extreme.
Or see here an analysis of medical ignorance in
Florida, ignoring ascorbate pharmacodynamics, ignoring the scurvy. Kalokerinos
post mortem of baby Yurkos.
In cases of AA depletion and rapid oxidation to DHA
in the presence of toxemia and inflammation cascade the amounts of needed
life-saving AA are in the hundreds of grams per day by IV. Levy reports that
Liposomal AA (L-AA) is about 8 times more effective than IV on a molecular
weight equivalent dosage. L-AA should be
supplemented by oral AA administered every few minutes in doses of several
grams per 100 kg of body weight.
Liposomal AA does not induce gut looseness. In case of toxemia from antibiotics killing
chronic infection microbes and releasing endotoxins, Angiotensin Release
Blockers (ARBs) are helpful as an adjunct to reduce the immune cytokine
cascade.
AA in the blood is stored/released quickly, it is
blocked by sugar, and excess if any is excreted rapidly. Studies that show “AA is resident for weeks”
are not relevant to the acute-infection conditions, toxemia, venom poisoning,
hyper allergy flares, COPD exacerbations, and to the poly-infected, subclinical,
scurvy-state of older persons and certainly not for the physiology of rapid
onset scurvy and anaphylaxis.
If oral AA intake is in the GI tract, too much can make your gut loose. “Too much” is highly variable over a range of more than 200 to one, depending on medical (disease) condition. AA in too high levels causes a gut purge, changing the gut environment. Natural gut purging during an illness is not a bad thing if you are prepared to reboot the gut with probiotics.
Take less AA and things go back to normal. The intake level at which the loose bowel condition occurs depends on AA utilization and on the ROS oxide chemical stress levels inside the body. The RDA recommended daily allowance is a single number based on long-term low AA input and non-depleted AA storage in the body, that is only for healthy persons with negligible ROS and stresses.
The high range of pathological, condition-driven AA-needs (scurvy) calls for much more AA than can be stored. A hypothetical 100 kg (220 pound) stressed rat would make 17-20 grams of AA from glucose in its liver, continuously, over the day as it is consumed neutralizing toxins and stress in the rat. Sometimes sick rats need even more.
So it is reasonable for people to take AA continuously at this level, possibly higher. Normal diet does not even come close to supply this much AA. Hyperglycemic (diabetic) conditions block and reduce AA cellular uptake and absorption, requiring additional >3 to >6 grams of AA daily to reach dietary minimal effectiveness. AA and CoQ10 work together to protect intracellular mitochondrial DNA from damage. See Ely.
After about a half hour after intake, AA is working
and within 1 hour the intake is fully in your blood. Antioxidant AA concentration in the blood is
highly variable. AA is absorbed by store-house
organs, the adrenal glands and the eyes, where vision changes may be
quickly evident. The first time I
started a high dose (3grams) of AA, ½ hour
later my eyes had snapped into focus. The lenses of our eyes are AA
storehouses. You may be able to use the changes in focus as an indicator of AA
changes, to remind you that you need to eat some more AA.
Reactive oxide species (ROS and NOS) molecules
metabolize AA. When they come in contact with AA molecules, they convert the AA
to the dehydroascorbic (DHA) form, which is a mild oxidant. The spent, metabolized DHA may be absorbed by
infected cells and by microbes where it is lethal.
Excess DHA is also excreted in the urine. Tests for
antioxidant AA in the urine do not react to the DHA. Coincident with large AA intake, a failure to
find active AA(reducing) in the urine is an indicator of its consumption
fighting infection toxins and oxides.
Cancer cells in tumors have a huge uptake appetite
for DHA, converted from AA. DHA then kills the cells in the tumor, acting on
the cancer cells mitochondria. AA in
normal cells, in the absence of inflammation, is non reactive and it does not
endanger cells, but has a protective action against toxin and allergens. AA(reducing)’s cellular uptake is much lower
than DHA(oxidizing).
When the blood has excess AA and the storage
threshold has not been achieved, it is quickly stored for later use. Accounting
in part for the short blood half-lifetime as it is absorbed into the
storehouses. When the body has a shortage, or an organ under attack (or a
tumor) has a shortage, the AA moves from the storehouses to the blood and to
the place of need where it is oxidized and metabolized. The DHA form is sucked into infected/cancer
cells and helps them to die. The die off causes toxins to be produced. More AA
is needed to neutralize the toxins. Excess DHA form passes back to the lymph
and blood and is later excreted through the kidneys.
When we are very healthy and contain few or no
microbial parasites and chronic infections, we might get by with about 100
milligrams per day. Building up quite a stored reserve. When the reserve goes critically low, blood
levels drop and we start to feel uncomfortable.
When we are borderline depleted and when we encounter an allergen, we
have an allergic attack. If we have
asthma or hay fever, we are chronically low in AA. When we have high AA
reserves, we do not have any hay fever. Asthma attacks are less frequent.
When AA levels are low (scurvy), cortisone levels
increase, suppressing the immune system. This reduces the ROS oxide production. This makes it easier for invading microbes
and chronic microbes to replicate. We get sicker, producing more reactive
oxides, which further deplete the active AA that is left. Histamine levels rise to have a protective
effect for some cells. When AA levels
pass a too-low threshold level, ROS and histamine levels rise
exponentially. Taking antihistamines
stops the histamine but not the oxides. You need more AA for the oxides.
If we were
sick with a hemorrhagic fever like Marburg
we might need 250 grams of AA per day and that amount might not be
enough.
When you have cancer you need a lot more AA to feed
the tumors and if it is not supplied frequently and enough, you die of scurvy.
AA taken frequently for end stage cancer will ease the misery related to the
scurvy state created by the cancer stealing the AA from the rest of the body.
At still higher IV levels, 100-200 grams/day, AA in
the form of sodium ascorbate kills the cancer cells. IV administration and AA
injections can get the blood AA levels much >10x higher that that of oral
administration. Past failed AA tests
used oral administration; successful tests used IV administration. The needed
blood levels could not be obtained by oral administration. Both ways used
together worked best.
When you are acutely sick, you burn AA rapidly, and
any stored AA is sucked out of the storehouse organs. You feel this as a
feeling of sickness until it is replaced.
If your brain, eyes, and body have a dull ache, this is the sign of
depleted AA. When I get the flu, I take
six+ grams of AA every 2 hours and the discomfort eases or almost vanishes. I
used to have low AA levels and hay fever during pollen season. With high AA levels, I have never again had
seasonal hay fever, for 45 years.
The Pub-Med
abstract that says that AA’s blood-concentration half-lifetime is ½ hour
although correct for the conditions measured, is only true for a small domain
of conditions. In the dynamic-AA-needs
world of pathologic-condition-nutrition any precise dosage is likely to be far
too low. The pharmacodynamics of AA in
vivo is highly dynamic and highly circumstantial as immune system generated
toxins continue to cascade.
If the ~100 gram RDA were to be an equilibrium input for healthy
persons, with a high balance of stored AA in their system, the half-life of ½ hour
would be related to intake and excretion
alone. Actually a low blood-level of AA is supplemented from stored reserves
which are replaced by inputs eaten infrequently.
Some info-sources now recommend a healthy person RDA of about 3
grams. Older folks with many microbial
parasites (chronic infections with inflammation) need 6 to 12 grams or more per
day. Some toxins need high AA intake to
fully neutralize ROS produced by the toxin-induced die off and to neutralize
the toxin itself.
Active AA in the blood is diminished by transit to storage, by
metabolism in attacking oxides, and by excretion. Klenner himself tested
active AA excretion in the urine with Benedicts reducing
glucose test, while he was applying high AA dosages for very sick persons.
He used frequent urine tests as a dynamic indicator of how much AA to use. He found that during the illness, while he
was putting large amounts of AA into the patient, that none showed in the
urine. After resolution of the illness,
reducing AA started showing in the urine, and he knew that the recovery was
almost complete.
It is illuminating to compute how long AA can stay in the blood at
effective levels. Pretend that the ½
hour half-lifetime is correct. A
two-hour delay after AA administration implies a depletion to 1/16 the initial
level. An eight-hour delay in re-intake
means the AA blood level depletes to near zero.
In the presence of a systemic acute disease condition, the AA is much
more rapidly oxidized than given in the numbers below. This shows why frequently repeated
(never-a-missed-dose) oral AA supplementation is needed. If no added intake,
Hrs/Depleted-to-Level% = .5h/50%; 1h/25%;
1.5h/13%; 2h/6%; 4h/.4%; 6h/.02%; 8h/.00% = 2.5*2-15%.
This means that once a day AA intake in AA
depleted (scurvy) state the level next day is 1/248. This also means
that if you are sick and are attempting to follow Klenner and Cathcart’s
practice, you must use valid pharmacokinetics and have to have oral intake as
often as every 2 hours as they recommended.
Other studies indicate that, if not in the
scurvy state, oral input dosages larger than 3 grams do not raise blood levels
much more. However, other studies found that the oral inputs may still raise
tissue AA with inputs greater than 3 grams at a time. In the scurvy state, oral inputs move rapidly
from blood to replenish depleted tissue AA levels, accounting for the failure
of blood levels to rise above the observed limits. So higher AA oral dosages are still
recommended if you are feeling sick.
Think of AA as a food and eat some with every meal.
Many of the historic diet AA testing
experiments are worthless, because they failed to use therapeutic amounts,
method, or frequency of AA administration. Most experimenters were testing the
depleted (empty bucket) AA state and thus their “AA is useless” findings are
falsified by their faulty methodology. Eat
250 milligrams and measure blood 6 hours later, you have [½]12 as a depletion factor; this is ~1/4000 th the
dosage and a 15% gut to blood transfer rate multiplier to boot. Not enough AA molecules to have any effect
against a venom or toxin with oral administration of water soluble AA.
Klenner, Cathcart, Pauling, Kalokerinos
confirmed each other, using appropriate pharmacokinetic intake levels and frequencies. Others throughout the world have confirmed
these scientists, if they follow their methods and/or exceed their dosages and
frequencies.
If you do meta-studies of a bunch of
now-falsified “AA-failed” studies, you will have produced incorrect consensus-supporting
conclusions. Thus the mistakes have
propagated for a period of about 65 years.
Bad science was in a falsified-concept feedback loop. “Absence of evidence” is not “Evidence of
absence”. We can’t be all wrong. But
most of the consensus was wrong and the consensus was ignoring
published successes. See the reasons.
The AA ignoring continues. Some savvy
nutritionists worry that an effective nutritional AA modality might be
suppressed based on regulator prejudice, ignorance or the drug companies’
lobbying to limit effective and low cost competition.
John Ely has a paper discussing neglected Unprofitable
Modalities of medicine that are underutilized, greatly to our
detriment. See: On the Science of
Essential Nutrients By John T.A. Ely. These treatments are so inexpensive that no profit
exists in providing them.
He defines the change in our diet around 1910
when more sugar and refined starches came into vogue. Current “normal” glycemic levels are high
compared with the levels of 1910. Hyper
glycemic high glucose levels block the action of AA, making it necessary for
intake to be higher than 10 grams per day.
The way to successful treatment is to apply
Aggressive Glucose Control (AGC) by reducing carbohydrates to the levels of
benign ketosis. This is Dr. Atkins’ induction stage diet. See Ketonic AA
Protocol. Numerous animal life
experiments show significant extensions by underfeeding them.
The benefit of AGC is to enhance the effect
of AA as an antibiotic/antiviral and to help DHA uptake into infected and
cancer cells, where the oxidized AA (DHA) acts to kill the cell invading
dysfunctional mitochondria, and to enhance the immune cell functionality to
attack invading microbes. With AGC, the AA below the 10 grams per day intake
level, the AA has its normal protective, anti toxin and immune stimulation
benefits.
AA and CoQ10 increase oxygen
transport.
Persistent chronic
infections create persistent inflammation conditions. This hyper inflammation
accelerates the AA depletion and creates a high level AA intake
dependency. Normal RDA vitamin C in diet
is inadequate. AA depletion accelerates
if large and frequent new AA is not eaten. See
case history.
In COPD treatment, insuring
high blood oxygen levels is very important. For about $25, a finger O2
percentage measuring instrument can be ordered from China on Ebay. You can then
see your O2 levels and pulse rates at any time. We have found that
by increasing AA intake to 2 grams every 2 hours for a 130 pound 90 year old
COPD sufferer, and by taking 100 mg of CoQ10 each day, that energy and heart
function improved from 86% to 94-97% O2 within one week after a heart attack.
Another rule for taking
vitamin C is if there is a shortness of breath, a cold, a coughing fit, throat
irritation or itch, any muscle or arthritic pain increase, inflammation
redness, welt, rash or hives, allergy attack, insect bite itching, sunburn,
COPD exacerbation getting worse, feeling of sickness, you have run out of antioxidant AA and need to eat more, at least
several grams more, the amount depending on the seriousness of the discomfort.
AA tunes up the red blood
cells. It works to kill the infected
RBCs (See Table A, Malaria) It detoxifies the HEME
from carbon monoxide poisoning and smoke inhalation. It helps in the absorption of nutritive iron
and in building new RBCs to replace the defective ones.
Some persons take AA in one
small dose and think they are allergic to it. It induces a die off of microbes
with toxins generated. This means more AA is needed. But if only one RDA sized
dose of AA per day is taken, this is not enough. AA depletes rapidly.
They do not take more AA but
less, and feel that they are allergic to the AA. This allergic flare may be because the AA
reserves are depleted by a Herx reaction to the small dose of AA. Or possibly citric acid is in the formulation
and this is the allergen, not vitamin C.
The real situation is they are allergic to a shortage of AA.
Take antihistamines and
frequently repeated doses of grams of vitamin C to see if this helps.
It may help to back off the AA and then restart a
few days later, repeatedly every several days, like an allergist will do when
training you to get over a specific allergy with the shots.
Cold-stress
depletes ascorbate (AA); Low AA in blood re-activates dormant microbes; active
microbes trigger allergenic immune defenses, exacerbate respiratory
inflammation, and elevate histamine. The
cold resembles an exacerbation of COPD, where a complex of viral and bacterial
chronic infections lay dormant, and then the immune system fires up and
microbes start replicating.
Cold/ COPD Solutions: Suppress immune system, Block signaling: microbes to immune-cells; Angiotensin Release Blockers ARBs like Benicar; Therapeutic (repeated 1-3 hours of 3 grams) amounts of ascorbate (AA= vitamin C); CoQ10 > 50 mg to improve heart function and increase O2 supply; Zinc supplementation; Antibiotics vs. viruses (RSV) and bacteria (Strep & Mycoplasmas).
L-AA provides a new therapeutic range AA dosage potentiating chemotherapy against degenerative diseases where microbes infect cells and against cancers of many types that have mitochondrial dysfunctions.
DHA is transported into the cancer cells via the sugar import mechanism. In cancer and microbe infected cells DHA oxidizes mitochondria and kills the cell. In normal cells the DHA is converted back to AA and is stored, so it can protect the cell.
Therapeutic range continuous AA blood levels need to be maintained as high as the lethal concentrations found for in vitro killing of cancer cell lines. These levels are of the order of 1,000 times the RDA (~100 grams per day, for many days) for vitamin C if IV sodium ascorbate is used. If Liposomal AA is used, 10 times less L-AA can be administered orally along with oral AA in frequent multi gram doses.
This treatment is successful both with and without chemotherapy. If used with chemotherapy, smaller amounts of AA will ease the patient’s discomfort while at the same time put additional oxidative stress on the cancer cells mitochondria.
“Reactive oxygen species (ROS)-induced mitochondrial abnormalities may have important consequences in the pathogenesis of degenerative diseases and cancer. Vitamin C is an important antioxidant known to quench ROS, but its mitochondrial transport and functions are poorly understood. We found that the oxidized form of vitamin C, dehydroascorbic acid (DHA), enters mitochondria via facilitative glucose transporter 1 (Glut1) and accumulates mitochondrially as ascorbic acid (mtAA). The stereo-selective mitochondrial uptake of D-glucose, with its ability to inhibit mitochondrial DHA uptake, indicated the presence of mitochondrial Glut. Computational analysis of N-termini of human Glut isoforms indicated that Glut1 had the highest probability of mitochondrial localization, which was experimentally verified via mitochondrial expression of Glut1-EGFP. In vitro mitochondrial import of Glut1, immunoblot analysis of mitochondrial proteins, and cellular immunolocalization studies indicated that Glut1 localizes to mitochondria. Loading mitochondria with AA quenched mitochondrial ROS and inhibited oxidative mitochondrial DNA damage. mtAA inhibited oxidative stress resulting from rotenone-induced disruption of the mitochondrial respiratory chain and prevented mitochondrial membrane depolarization in response to a protonophore, CCCP. Our results show that analogous to the cellular uptake, vitamin C enters mitochondria in its oxidized form via Glut1 and protects mitochondria from oxidative injury. Since mitochondria contribute significantly to intracellular ROS, protection of the mitochondrial genome and membrane may have pharmacological implications against a variety of ROS-mediated disorders.”
See our additional Web notes on AA vs Cancer.
The site, DoctorYourself.com, has material documenting successful high dosage AA IV treatments. See: Intravenous Ascorbate as a Chemotherapeutic and Biologic Response Modifying Agent by The Center for the Improvement of Human Functioning, International, Inc., Bio-Communications Research Institute.
Successful application of AA IV to treating various cancer conditions needs to meet the criteria below.
Criteria: A valid treatment-trial
should include providing tested (not assumed) blood AA levels that are high
enough concentrations to exceed the killing concentrations for cancer cells in
vitro. Papers exist with in vitro cancer-cell-killing
AA concentrations published for various cancer cell lines. The duration of the AA blood levels at a
killing-concentration must include several hours each day of maintenance at
more than the effective concentration. They should also include oral AA intake
at high levels at <3-hour intervals to avoid AA depletion between IV
sessions. Between IVs injected AA may be substituted for oral intake. [Here AA stands for buffered AA, with
proper attention to IV minerals balance in blood serum]
Comment: Dr. Levy says Liposomal AA is 7-10 times more effective per gram of AA than a gram of IV
AA in sodium ascorbate administered. Thus 2 grams of L-AA may be as effective as
10 grams of IV AA in fighting a virus because the lipid coating of L-AA
provides a better penetration of the lipid coating of the virus.
However, when neutralizing toxins, the number
of molecules of AA is important vs. the number of molecules of all the toxins
and cascade oxides, etc. In this case IV
sodium ascorbate and L-AA would be approximately equal in their
effectiveness. Additional use of oral AA
and IV AA together will get more molecules into the blood fastest. Speed is
important. L-AA is used for follow up therapy, after the toxins and venoms have
been neutralized using IV sodium ascorbate to get the most AA into the blood as
fast as possible.
In Cellular Health
Series: Cancer by Matthias Rath,
MD, has an illustrated color insert:
The Victory Over Cancer is at Hand.
Microbes invade the host’s leukocytes (macrophages)
and/or other (liver, tissue, etc. cells), take over intracellular gene-driven
enzyme production, and produce an imbalanced chemical dysfunction. Rath, in the
insert, describes how a nutrient cocktail stops the destruction of tissue by
viral-infected cancer cells. The cocktail ingredients are a combination of
L-lysine, L-proline, Vitamin C and Epigallocatechin Gallatin (EGCG, a green tea
extract). AA disables the
spreading-factor enzyme, hyaluronidase produced by viruses, cancer cells and
bacteria. Hyaluronic acid is a long chain sugar molecule that is one thread in
the three-dimensional woven-matrix that makes up the structure of our
tissues. If you combine hyaluronidase
and a few select protein-eating enzymes you can dissolve the tissue that is
generated to wall off tumors. Cancer
cells generate all of these enzymes to facilitate metastasis. The Lysine and Proline act as targets for
these protein-eating enzymes, blocking their action on tissues. Hyaluronidase
(HD) enzyme is made by microbe parasites. It digests the hyaluronic acid
lubricant packing the joints that protects cartilage.
AA plus
L-lysine is known to facilitate healing of Herpes-caused lesions. AA disables the HD in your system, slowing or
stopping germ spreading and protecting the HA packing the joints. It also plays a role in rebuilding tissues
and joint cartilage. AA also speeds
wound and surgery healing, and facilitates stem cell differentiation into
target cell forms in healing joints and tissues. AA is a universal and
quick-acting anti-toxin with an incredibly wide-range of toxin neutralization
applications documented by Klenner. See Table A for a list of toxins. Also see: Early
Clinical Usage of Vitamin C by Dr Frederick Klenner.
It
is surprising that emergency room doctors inject adrenaline to stimulate AA
release from our glandular storehouses instead of using several gram amounts of
AA instead. Many physicians are taught
that adrenaline works but are not taught that much of the benefits are from
induced AA release and that more AA injected directly will work better and in a
unlimited dosage needed for more serious crises.
Likewise
for anaphylaxis, serious poisonings, snake and spider venoms, smoke inhalation,
and carbon monoxide blood poisoning, and the like, a rapid IV push
of grams of sodium ascorbate is essential; Klenner used 10 to 20 grams at a
time to reverse anaphylaxis, with remarkable and speedy success.
All humans lack the
essential gene to make AA, so we all must eat AA several times each day in
sufficient levels appropriate to our daily needs. First, AA is an antioxidant and
it disables the reactive oxidizing species (ROS) and all toxins that it
encounters. Next it has a huge number of additional biochemical actions. Including healing in heart
disease.
Depends on body weight and conditions.
Use
ratios:
Your Suggested Daily Intake (Grams) = [Your weight (Kg)] x [17 (grams)/200 (kg)] if you are well.
If
you are almost Well: 6 to 17 grams for a 200 lb = 100kg person.
According to Vojdani and Franco, Six grams of AA per day, at a minimum, will begin to restart the immune system’s T-cells’, B- cells’, and Macrophages’ recovery from the mitochondrial dysfunction (MD) that is a result of various microbes invading these immune system cells. These are white blood cells. 6 grams/day = 4x500 mg tablets (= 2 grams) every six waking hours, 3 times/day. For higher levels you may wish to build up slowly to bowel tolerance; or take smaller doses more frequently. If diarrhea occurs, decrease by 1 gram, use more frequent doses and work up to higher levels. This a loose gut indicates your individual tolerance. Spread the dose over the day for maximum intake and benefits.
A typical daily multi-vitamin contains only 50-100
mg of vitamin C. This is 1/20th to 1/10th gram, just
enough to prevent scurvy if you are healthy, but not nearly enough to
neutralize serious oxidative stress or to prevent infections and other
illnesses. The best form of vitamin C is the one most readily absorbed. Timed-release forms of AA are useless.
Powdered AA in gelatin capsules is better than
pressed solid pills. Buffered powder
(e.g., Ester C is calcium ascorbate) is available under various house brands,
although sodium ascorbate is preferred.
All of these are available online and frequently quantity discounts are
available.
If
you are Acutely Ill or have Toxins, Toxemia, Carbon Monoxide or Venom Poisoning: IV and/or Liposomal form.
· Up to 100 grams per day.
Divide the daily dose and administer 6 to 16 times per day. (1-3 hours between
oral doses)
· If seriously ill or in shock
front-load with higher IV or injected sodium ascorbate amounts at the
start.
· Use AA injections, IV drip
and AA by oral intake together in appropriate coordinated doses.
·
Inject
Intra-Muscular and/or inject Intra-Venous solution (for shock, lethargy and for
unconsciousness)
Chronic: Fibromyalgia, Chronic
Fatigue Syndrome, Lyme disease, Taking Statins, etc
Depends
on the condition, see Dr. Cathcart’s table below: Also supplement with CoQ10 to help
mitochondria energy.
Acute
Illness: Oral
dosage to ramp up without limit until bowel tolerance level is determined. Start at dosages depending of severity of
illness, per Dr. Cathcart’s table.
Severe colds may need 30 to 100 grams/day. If your
gut does not go loose, you are below the maximum that you need. If you take AA by injection it does not
affect the gut.
Powder form
ascorbic acid in water, 2 tablespoons Vitamin C powder/hour for two days to
several weeks, then decrease gradually. Quitting abruptly might result in
“induced-scurvy” feel-bad condition. So taper down.
Always carry AA on trips, and if headache or
allergic attack or sinus headache, your system is out of AA and you need to
resume prior high AA intake levels.
Vitamin C potentiates antibiotics, it reduces allergic reaction to their use, and in high and frequent dosages it stops bacteria spread. It works to moderate the oxides and toxins produced when the microbes die from the antibiotic actions.
Chronic
Illness:
Polymicrobial infections may need 6, 12, 18, 24, or 32 grams per day of Vitamin
C, with dosages evenly spaced (every 1, 2, 3 or 4 hrs). Timed-release tablets
are worse than spaced dosage; it releases more AA in the lower intestine, past
the region of maximum absorption. Duration of use of Ascorbate for serious
chronic intracellular infection and cancer may be til end of life. Transport
percentage from gut to blood depends on the dosage and the degree of need
(scurvy state). Higher water soluble AA dosages may not all be absorbed.
Therefore smaller dosages taken more frequently will be better absorbed than
large dosages taken less frequently.
Liposomal AA is absorbed 5 times better and has no loose gut effect,
thus the maximum dose can be several grams per hour. The limiting factor may be
the effects of too much lecithin, oily skin.
Dose
Interval = 24 Hours/ # of Doses.
Source: Dr. Cathcart’s research at http://www.doctoryourself.com/titration.html
|
ACUTE
CONDITION |
GRAMS
ASCORBIC ACID PER 24 HOURS |
NUMBER OF ORAL
DOSES PER 24 HOURS |
Time Between
Doses (16-18
hour Waking-day) * |
|
Normal |
4 – 15 |
4 – 6 |
4 - 3 hrs |
|
Environ/food allergy |
0.5 – 50 |
4 – 8 |
4 - 2 hrs |
|
Anxiety, mild stress |
15 – 25 |
4 – 6 |
4 - 3 hrs |
|
Mild cold |
30 – 60 |
6 – 10 |
3 - 1.5 hrs |
|
Severe cold |
60 – 100+ |
8 – 15 |
2 - 1 hrs |
|
Influenza |
100 – 150 |
8 – 20 |
2 - .8 hrs |
|
Coxsackie virus |
100 – 150 |
8 – 20 |
2 - .8 hrs |
|
Mononucleosis EBV |
150 – 200+ |
12 – 25 |
1.5 - .7 hrs |
|
Viral pneumonia |
100 – 200+ |
12 – 25 |
1.5 - .7 hrs |
|
Hay fever, asthma |
15 – 50 |
4 – 8 |
4 - 2 hrs |
|
Burn/injury/surgery |
25 – 150+ |
6 – 20 |
3 - .75 hrs |
|
Cancer |
15 – 100 |
4 – 15 |
4 - 1.2 hrs |
|
Ankylosing
spondylitis |
15 – 100 |
4 – 15 |
4 - 1.2 hrs |
|
Reiter's syndrome |
15 – 60 |
4 – 10 |
4 - 1.2 hrs |
|
Acute anterior uveitis |
30 – 100 |
4 – 15 |
4 - 1.2 hrs |
|
Rheumatoid arthritis |
15 – 100 |
4 – 15 |
4 - 1.2 hrs |
|
Bacterial infections |
30 – 200+ |
10 – 25 |
1.6 - .7 hrs |
|
Infectious hepatitis |
30 – 100 |
6 – 15 |
3 - 1.2 hrs |
|
Candidiasis Yeast |
15 – 200+ |
6 – 25 |
3 -.7 hrs |
Highest
levels require IV administration. This
is a guide. You should seek Professional Medical Support to administer high
levels of AA by injection or IV. Check
the web for doctors in your
community. Look for orthomolecular and
nutrition oriented doctors and clinics.
*To
minimize overnight AA depletion, take oral AA at bedtime and first-thing when
awakening.
Also
take a dose if awake middle of night to
urinate.
See our discussion of an AA Ketonic
Protocol
Ketosis
plus vitamin C (AA) is an adjuvant to the Tetracycline-antibiotic protocol.
Combine Klenner's AA and Rheumatoid Arthritis: The infection Connection,
Appendix 2 antibiotic protocol. Benign ketosis is induced by drastic reduction
of carbohydrate intake. [Atkins-diet induction stage, < 10 grams
carbohydrates/day] The liver shifts from fat storage mode to fat extraction
mode and fats and proteins are catabolized to acetyl CoA to feed the Krebs
cycle where ATP is made to feed energy to all the body cells. Body-cell sugar
use shuts down. Hypoglycemic condition stops in ketosis mode. Microbes and
viruses are sugar dependent, so are drastically starved. ROS of the sickness
oxidizes the AA to the DHA form. Microbes, microbe-infected body and cancer
cells need sugar and ingest oxidized Dehydro Ascorbic Acid (DHA) instead.
Inside the microbes and the infected cells the DHA oxidizes the cells'
mitochondria and induces apoptosis (cell death). AA levels of about 28 grams
per day were used in one case history on our website in addition to the
Appendix 2 tetracycline protocol to reverse (cure) a severe painful bone-joint
resident infection of unknown origin in a period of 4 days. Eating
honey-covered peanuts was enough to re-trigger the pain locus. The protocol was
repeated successfully several times when relapse was induced by the sugar. The
periods of remission extended and severity of relapse decreased with each
repetition of the ketosis and the combined protocols.
The
problematic official “scurvy does not exist” and “low levels are enough” nutritional doctrine. Doctrine was established by measuring an
empty bucket. Blood level variability
changes ‘presence’ to ‘absence’ within a few hours. Many conflicting studies were made at too-low
or depleted levels, they assumed AA was present. But it was not and when no
effect was measured with AA absent, they
failed to measure blood AA levels, just assumed “AA was present” when it was not. Then they
labeled AA as ineffective when it was AA depletion, not AA presence that was
measured. Some AA supplement studies
conflict in results, indicating that AA plus other nutrients together may be
needed. Some AA statistical studies
conflict with our knowledge of functional biochemistry findings.
Since high blood sugar, hyperglycemia and
diabetes, so strongly interfere with AA uptake and effectiveness, there are
problems of under appreciated, much higher needs and of dependencies due to
chronic and acute illnesses, toxic/anaphylactic shock syndrome, persistent
hyper-allergic states, or persons suffering from poisons or
insect/snake/fish/plant toxins. The
discussion of AA blood levels for anticancer treatments recognize that at high
levels, AA can act as a powerful anti cancer drug.
See Ely, Klenner and Cathcart below.
“The Recommended Daily Allowance (RDA) for vitamin C
is 60 mg/day, an amount associated with plasma vitamin C concentrations ranging
from 28 to 34 μmol/L. Plasma vitamin C concentrations ranging from 11
μmol/L to less than 28 μmol/L represent marginal vitamin C status,
which Jacob defines as a moderate risk of developing vitamin C deficiency due to
low tissue stores. Plasma vitamin C concentrations less than 11 μmol/L are
indicative of vitamin C deficiency. The average daily intake of vitamin C in
men in the United States is about twice the RDA, yet the prevalence of vitamin
C deficiency and marginal vitamin C status in men is 13% and 24% respectively.
Women consume an average of 90 mg vitamin C daily, and the prevalence of
vitamin C deficiency and marginal vitamin C status in women is 9% and 18%,
respectively. These data indicate that although the average vitamin C intake in
adult men and women is adequate, vitamin C deficiency and marginal vitamin C
status are strikingly prevalent in these populations.” -- Roman Bystrianyk
Persons who have marginal vitamin C levels in blood
are suffering from either inadequate AA input or chronic infections that
produce a toxin load and production of oxides by the immune system, or
both. These are the persons likely to
have a depressed immune system and are at risk of an adverse event after
vaccination. They are vulnerable to allergens, hay fever attacks, and are more
likely to become a cold/flu epidemic victim.
Rapid
Onset Scurvy induced by Reactive Oxide Stress, as indicated in the conditions
above almost instantly converts AA into the inactive oxidized form and in cases
where there is little or no AA stored in tissues, this can result in grave
complications to infections such as pneumonia, toxic shock, vaccine shock, and
systemic infections.
[2012,
Seven years later, Still no corrections to flawed publications and stonewalling
by the FDA/NIH researchers still continues:
“Had they exhibited any
integrity, NIH researchers should have written medical journals and retracted their previously
errant studies. They didn’t. They should have alerted the Food and Nutrition
Board that the Recommended Dietary Allowance for vitamin C needs to be
re-evaluated. They didn’t. They should have alerted the news media. They
didn’t. They should have withdrawn now erroneous printed publications and
website pages that continue to air the misinformation. They didn’t.
“Even after being prodded for over a year by fellow
scientists, Drs.
Steve Hickey and Hilary Roberts from Manchester, England, the NIH researchers took no corrective
action.
“Hickey and Roberts reacted
by writing a book on vitamin C
(Ascorbate: The Science of Vitamin C,
available as an e-book at www.lulu.com/ascorbate $6.00 US funds) that documents the scientific
mistakes made by NIH researchers….”
The 2004 petition from noted scientists to NIH remains a milestone marking the start of a new period of official failure to respond, similar to that noted by Linus Pauling in 1977.
Health Supreme by
Sepp Hasslberger [2004]
HALF-LIFE
FOR VITAMIN C IGNORED:
The
main flaw -- the half life for vitamin C is quite short, about 30 minutes in
blood plasma, a fact which NIH and IM researchers have failed to recognize.
(Half life is the time it takes for half of a substance to be removed from the
body.)
NIH
researchers established the current RDA based upon tests conducted 12 hours (24
half lives) after consumption. "To be blunt," says Hickey, "the
NIH gave a dose of vitamin C, waited until it had been excreted, and then
measured blood levels.
Because vitamin C is used up rapidly, a very
high single dose of vitamin C would not achieve the same concentration in the
blood serum over time as two divided lower doses. Hickey and Roberts claim many
negative studies using high-dose vitamin C have failed to recognize this fact
and have therefore mistakenly concluded that high-dose supplemental vitamin C
is ineffective.
RDA
NOT FOR EVERYBODY:
[Too
low amount to be therapeutic and blood level depletes to .000001 in 10 hours;
gut to blood transfer factor is <.15]
In
the past year Hickey and Roberts have shaken the confidence of the IM and NIH,
revealing that the medical establishment has failed to investigate the use of
high-dose vitamin C properly, for more than 50 years. Hickey and Roberts have
taken the IM and NIH to task for developing the RDA for vitamin C on studies
using only 15 healthy test subjects. Normal variations would call for a greater
pool of test subjects before establishment of an RDA for hundreds of millions
of people. [Functional reactivity and rapid oxidation of ascorbate not
accounted for in long term low dose statistical studies]
Furthermore,
the RDA is intended to set a level of nutrient consumption that would prevent
disease (scurvy) among the vast majority (95%+) of the population.
Special
groups have increased need for vitamin C and comprise more than 35 percent of
the population. The current RDA wouldn't meet the needs of these large
subpopulations:
Smokers
(50 million),
Estrogen
or birth control pill users (13 million and 18 million),
Diabetics
(16 million), pregnant females (4 million) and
People
taking aspirin (inestimable millions) or other drugs,.
[Arthritis
and rheumatic patients not counted but in tens of millions]
Flu
and Cold victims not counted but in millions
Asthmatics
and Chronically ill
Studies
of AA blood levels of hospital admitted patients show significant percentage
10-35% of presumably healthy population has AA levels critically low]-KFP
CONTRADICTORY
DATA:
Hickey
and Roberts confronted the IM and NIH with their own contradictory data.
The
IM and NIH claim the saturation point is reached at a certain concentration of
ascorbic acid in blood plasma but later published a paper showing repeated oral
doses could achieve much higher concentrations, more than three times greater!
[Annals
Internal Medicine 140: 533-37, 2004]
Because of the short
half-life of ascorbic acid, five 100 milligram doses of oral vitamin C taken at
intervals through the day will raise average blood levels more than a single
1000 milligram dose. Hickey says the blood plasma is not saturated when 1000
milligrams of vitamin C is consumed orally since NIH researchers themselves
demonstrated 2500 mg dose produces even higher concentrations.
[Orthomolecular
doctors recommend daily 50-200 mg per Kg body weight depending on age (older è
more) and on health conditions (sick è more).
That is, the amount a stressed rat would make per kilogram
(>15gm/100Kg), based on animal studies.
When daily input of this amount is spread over 16 waking hours, the
system is saturated, and normal toxins and allergies do not result in
significant inflammation or other toxemia effects, they are promptly
neutralized. Of course a venomous
snakebite would require more AA in proportion to the amount of venom injected,
and the lethality of the venom]-KFP
Hickey
and Roberts claim the minimum supplemental dose of oral vitamin C needed to
sustain blood plasma levels is around 2500 milligrams a day in divided doses in
healthy individuals.
[Since
sugar blocks AA transport, between meals and without food is better. AA in orange juice would have less effect
than AA by itself with water. Still the gut to blood transfer factor is <.15
except in the scurvy state. Transfer is
in intestine and lower intestine.]-KFP
Millions
of others (smokers, diabetics, etc.) have needs greater than this RDA. NIH
researchers doggedly cling to their claim that no more than 200 milligrams of
oral vitamin C is required for human health [per day] and that a diet which
includes five servings of fruits and vegetables would provide 210-280
milligrams of vitamin C. [Biofactors 15: 71-74, 2001] But only 9 percent of the
US population consumes 5 servings of plant foods daily.
The
National Cancer Institute has abandoned their 5-a-day recommendation and
replaced it with 9-a-day servings of fruits and vegetables once they recognized
five servings a day had not reduced the risk for cancer or heart disease.
[But
this amount is still not enough; also ends up promoting too many carbs and
calories]-KFP
TOLERABLE
UPPER LIMIT ALSO FLAWED: [Excuses malpractice by
medical practitioners]
The
recommended Tolerable Upper Limit for vitamin C, 2000 mg per day, gives the
false impression that amounts beyond this would be toxic or produce side
effects.
[There
is no practical upper limit of AA safety, hundreds of grams per day have been
used therapeutically for hundreds of thousands of patients without incident. In
fact the harm in giving AA is in giving AA in too small amounts and not
frequently enough. Patients who die
every day die because of oxidant form AA depletion. So many Doctors are
oblivious of scurvy.]-KFP
In
fact, 2000 mg of oral vitamin C would not meet the needs of millions of
American adults. The only side effect at this dose is transient diarrhea which
usually dissipates over time.
[Diarrhea
results if the AA is not absorbed in the upper intestine and gets to the lower
intestine. According to Cathcart the diarrhea comes on only at much higher
levels when more than several grams of AA is taken all at one dose. Spreading out the dose and taking more than
several grams at a time if you are AA depleted will not yield the
diarrhea. The diarrhea also purges the
gut of microbes and helps to regularize the gut flora based on an acid loving
microbiome. ]-KFP
TISSUE
LEVELS VS. BLOOD PLASMA LEVELS:
The
mistaken idea that high-dose vitamin C supplementation saturates the blood
plasma after a moderate dose of about 150 milligrams of oral vitamin C, and
additional amounts are worthless since they are excreted in the urine, now must
be abandoned, says Hickey and Roberts.
More
than a decade ago other researchers found that consumption of “high-dose”
vitamin C (2000 mg per day) increased ascorbic acid levels in the human eye by
22-32 percent compared to when a so-called “saturation dose” (148 mg) is
consumed. [Current Eye Research 8: 751, 1991]
Ascorbic
acid levels in other tissues in the body, such as the brain where vitamin C
concentration is 10 times greater than in blood plasma [J Clinical Investigation
100: 2842, 1997], make it evident that blood plasma levels may not be the gold
standard for measuring vitamin C adequacy in all tissues in the human body.”
[Liposomal
AA transfers about 95% with the loose gut not happening. L-AA and normal AA
used together in repeated dosages every hour can supply a therapeutic level of
blood AA for an indefinite period of time. Oral L-AA gram for gram is 7-10
times more effective as IV sodium ascorbate when used against microbes with a
lipid envelope. – Dr. Thomas Levy in a blog on the Vitamin C foundation]-KFP
And
increase medical delivery costs by slowing recovery from pathologies with
inflammation.
In order to achieve therapeutic dosages of AA, oral intake of Liposomal AA or IV direct infusions of sodium ascorbate needs to be administered. Cathcart, Klenner, Kalokerinos, Riordan, Saul and Levy have documented the methods. See Table 2, Reference 10, below.
|
Anti
Viral: Intracellular / Outside cells |
Antibacterial:
Antibiotic & Antitoxin |
Anti-Toxin: Neutralizing |
|
Viral hepatitis Liver’s antitoxin blood-cleaning uses up vitamin C. So Liposomal AA delivers more of the needed AA to just where it is needed, and if enough is taken the viral liver infection will be destroyed too. |
Diphtheria |
Vitamin
C Protects against drug reactions: Allergies and toxemias for Tetracyclines, Cypro, Sulfas, Penicillins,
Chemotherapy, etc. |
|
Polio -Klenner |
Pertussis = Whooping Cough (COPD like) |
Bacterial exotoxins: (All) |
|
Measles -Klenner |
Tetanus = Lockjaw |
Barbiturates and Alcohols Rapid
detoxification |
|
Mumps -Klenner |
Tuberculosis, also use Lauric Acid & enzymes like serrapeptase. Liposomal AA is better form. |
Carbon Monoxide and smoke inhalation AA
instantly reactivates Hemoglobin. |
|
Viral Encephalitis |
Malaria |
Nuclear Radiation: AA protects against damage; increases survival dosage. |
|
Chicken Pox and Shingles |
Streptococcal infections |
Burns and Sunburn |
|
Herpes: HV
1&2, CMV, EBV , Caposi’s sarcoma |
Rheumatic Fever |
Frostbite recovery |
|
Influenza: SARS, all varieties |
Scarlet Fever |
Endotoxin from gut and Herx release |
|
Rabies: In high frequent doses |
Leprosy |
Strychnine |
|
AIDS: High, Long-Term, With Lauric Acid |
Brucellosis |
Methemoglobinemia |
|
Hantavirus |
Lyme disease: Borreliosis, Helps to control inflammation, very persistent |
Tetanus exotoxin |
|
West Nile virus |
Chlamydia Pneumonia: Helps, very persistent |
Botulinum toxin |
|
Ebola and other Hemorrhagic fevers |
Trichinosis |
Cyanide and cyanosis |
|
SARS |
Protozoa: Giardia lambda, control antibiotic die-off Herx inflammation. |
Histamine: AA blood levels below critical level stimulate histamine release. |
|
Leukemia (viral) |
Listeria monocytogenes: Food treatment |
Nitrosamines: Depends on Ph, +/- effects |
|
Gut viruses |
Amoebic and Bacillary dysentery |
Mushroom & Mycotoxins |
|
Viral Pneumonias: RSV |
Salmonella: Food treatment |
Mold environmental toxins |
|
Coxsackievirus |
Pseudomonas |
Plant toxins poison ivy |
|
Klenner
maintained all viruses were vulnerable to high levels of IV sodium ascorbate.
Cathcart concurred in this opinion; Doses ranging to above 200 grams per day IV for hemorrhagic fever
viruses, like Marburg and Ebola. |
Rocky mountain spotted fever |
Insect
venoms: Bees, wasps, spiders, scorpions, etc. All if enough IV AA fast enough |
|
Cancer Viruses |
Staphylococcus infections. |
Snake
venoms: All, if enough IV AA fast enough Marine venoms: Box jellyfish; Fugu |
|
Hodgkin’s disease? |
Trypanosoma infections |
Heavy
metals: Chelates, mercury, aluminum adjuvants, lead, silver, copper,
magnesium, etc. |
|
Legionella pneumophila |
Calcium:
Facilitates bone healing (Boneset herb); Mobilizes
calcium |
|
|
Facilitates
stem cell differentiation to target cells |
||
|
Pesticides:
Wide range of protections; DDT adjunct, parathion, malathion, etc See Curing the
Incurable |
Katherine M Poehlmann, PhD and Karl Poehlmann
1.
Vitamin C
Pharmacokinetics and
Pharmacodynamics
|
2.
AA
Ketonic Protocol Factors Multi-factors for healing
|
3.
How
Vitamin C Works AA’s Functional
nutrition explained
|
4.
A 2nd Vitamin C Overview Well written 2nd
opinion
|
5.
Misdiagnosis:
Scurvy as SBS Shaken Baby Syndrome
|
6.
Vitamin C
Relieves Pain Our family’s case history
|
7.
West Nile Cure? IV and Liposomal AA: (Dr.
Tom Levy)
|
8.
Liposomal
Vitamin C Therapeutic breakthrough formulation
|
9.
Health
References Most-useful
health books and articles
|
10.
Authoritative
Nutrition Related to AA
and Inflammation
|
11.
Vitamin C Historic
Papers At Seanet.com
|
12.
Vaccines
and Inflammation Cause
Autism
|
13.
Post-Antibiotic Age: Germ
Theory Tim O’Shea
|
14.
Our
Nutritional Writings Listed
below
|
-- Klenner, Cathcart, Pauling, Stone
NUTRITION, ORTHOMOLECULAR AND
COMPLEMENTARY MEDICINE
NLM; LPI; JOM;
Enig; Links: Pauling, Ely, Klenner, Cathcart, Stone
TABLE
OF CONTENTS
1. National
Library of Medicine: Complementary Medicine Links
2. Linus
Pauling Institute @ Oregon State University Links
3. Journal of
Orthomolecular Medicine: Links
4. Mary
Enig’s Fats/Oils Papers: Google[enig coconut antiviral]
5. Vitamin C
Ortho-Molecular Nutrition: By
Klenner, Cathcart, Pauling, Stone
6. John Ely,
Medical Physicist: On Nutrition and Other Important Papers
7. Celiac Disease and Gluten Sensitivity: GlutenSyndrome.net
Back To Home Page
Back to Our Ongoing Research
Copyright KF and KM Poehlmann,
January 2013, all rights reserved.
Inflammation, chronic infections, nutrition and immunity are topics we have researched broadly in our studies of worldwide medical knowledge, documented on the Internet and in the historical archives of medicine. We have spent over ten calendar years reading about these inter-related subjects, attending postgraduate medical conferences. We have read countless medical texts, abstracts, papers, online in the National Library of Medicine and contained at various authoritative medical, nutritional and biological websites. The mass of the available information worldwide is tremendous. Search engines can reach much of it, so it can be correlated productively.
Nothing herein or referenced herein should be considered prescriptive for any medical condition. This information is for study and education purposes only. The readers are advised to find and consult well-educated, trained and licensed medical and nutritional practitioners who shall evaluate the many circumstances and conditions of each of their patients and will devise appropriate treatments and nutritional plans for them. It is recognized that each person has the right and duty to be well informed about the best foods, nutrition and medical practices available that will promote their own good health. The opinions expressed herein are those of the author(s) and the sources cited and there are many divergences of opinions on many topics. The readers must resolve the conflicts, in their own minds, after careful consideration of all the details and after any further necessary research and study.
More intermediate-level information is pointed to below, See Latest Findings and Free Articles.
Rheumatoid Arthritis: The Infection Connection (2001, and 2011) and
Arthritis and Autoimmune Disease: The Infection Connection (2012)
Latest Findings: » West
Nile Cure? » Liposomal
Vitamin C » Systemic
Plaque Cures?
» Hantavirus Epidemic ‘12 » Vitamin C
Pharmacokinetics » AA Ketonic
Protocol Factors
» How Vitamin C Works » A 2nd Vitamin C Overview » Misdiagnosis:
Scurvy as SBS
» COPD
Countermeasures » Vitamin C Relieves Pain » Video Liposomal
Vitamin C
» Vitamin C Foundation Videos
» AA vs. Cancer
Update » $83,000
Scorpion Bite
»
Nutrition Analysis:
Chocolate » Vaccines+Scurvy
= SIDS+SBS » Statins Cause
Harm
» Saturated Fats
are Healthful » Vaccines+Scurvy
= Autism+ASD » Fats
and Heart Disease
»
Adverse
Case Histories » Fixes for US Medical System » Burn Stem
Cell Treatment
» Nutrition
Table of Contents » Fix Obamacare Mistakes » Prenatal
Ultrasound Danger
» Mushroom
Poisoning, 2012 » E.coli endotoxins cause
SIDS » Cancer:
Reactivated Metazoa?
Tables: » Microbes
& Diseases » Cancer-Linked
Microbes »
Pauling's
Heart Disease Nutrition
» AA Relieves Coughing
Fits » Anti-Viral
Foods, Not Eaten » Endotoxins and Exotoxins
Recovery
»
Movie: “Forks Over
Knives” » Flu Vaccines
Cause Scurvy? » Vaccines Vs.
Nutrition
Ongoing Research (2002 – Present)
1.
Diagnosis-Checker Where to get a second opinion on the web.
2.
Dr Thomas
McPherson Brown Arthritis Institute Conference May 1991
3.
Dr Garth
Nicolson's Website and Papers Many important references.
4.
CCMRF 2005
PolyMicrobial Presentation Slides by KF Poehlmann
5.
Koch's
Postulates: Grounds for systemic
denial of reality?
6.
Arguing From
Minimized Statistics Leads to Problems and wrong conclusions
7.
Natural
Antiviral Foods, Herbs, Oils Where
to look to find medicine in food.
8.
Clinic at
WalMart: Low cost medical service and access to basic drugs.
9.
Nutrition,
Orthomolecular and Alternative/Complementary Medicine Web links.
10. Statins
Interfere with Cholesterol Functions & CoQ10 Production Age speedup.
11. Cancer vs.
Microbes: Table with references to medical WikiPedia.
12. Diseases/Conditions
Vs. Microbes: Table with references to medical WikiPedia.
13. Urinary Tract
Infections: Mycoplasmas and Ureaplasmas & drug
sensitivity.
14. Why Doctors
Might Not Use the Brown Antibiotic Protocol Many poor reasons.
15. Ketonic AA
Antibiotic Protocol with Nutrition Factors The math and the factors.
16. Gut Bacteria and
Health Countermeasures Reboot the gut with probiotics.
17. Metallo Enzymes
a Complex of Active Molecules Plus and minus roles.
18. Gut Bacteria
Metabolic Syndrome, Heart Disease and Lecithin Surprise!
19. Vaccines +
Mitochondrial Dysfunction Cause ASD & dysfunction of the Vaccine Court.
20. Vaccines Cause
Chronic Hyper Allergy A long-tail statistical certainty.
Vaccines
hyper-sensitize to disease agents Many examples in the literature.
Vaccines hyper-sensitize to
food proteins Antibodies target nerve sheaths.
Proof: Macrophagic
myofasciitis Lesions Adjuvant at
injection site persists.
Cumulative Aluminum
Persistent Toxicity Adjuvant-caused immune hyperactivity.
Causality is denied as a mystery, focused studies un-funded and unread.
21. Vaccines Vs.
Scurvy Notes Plus Kalokerinos
related URLs.
22. Heart Disease And
Fat Nutrition Falsified theories cause harm.
23. A Revolution in
Our Understanding of Oils and Nutrition A sea change.
24. Kefir and
Related Probiotics Fermented milk microbes some helpful, others
misunderstood.
25. Vitamin
C (Ascorbic Acid = AA) IV Protocols for Cancer AA vs. tumor cells.
26. PubMed: Ascorbic Acid: Anti-tumor, Anti-angiogenic,
Pharmacokinetics:
27. Vitamin C
PharmacoKinetics and PharmacoDynamics: How AA works.
28. COPD, ASD,
& Infections: Diet & Countermeasures.
29. Mycoplasma
Photomicrographs Links to Pictures.
30. CWD L-Forms
History Who found What.
by Amy Proal Link to website.
31. Lyme
Disease Perspective Great overview by Dr Scott Taylor, DVM; & more.
32. Lyme Disease
Borrelia Burgdorferi Information and Pictures.
33. A
Remarkable Success: Reverse dementia by Ketosis diet and Coconut oil.
34. Jenna’s
Lyme Blog Articles
LymeDiseaseResource.com/
35. Colorful Lyme
Lecture by Alan McDonald, a pathologist. (2007)
36. Marshall
Protocol Inflammation in RA, Fibromyalgia, and Sarcoidosis.
37. Chlamydia
pneumoniae Linked to Heart Disease, Stroke, and Alzheimer’s.
38. Candida Yeast
Infection Aggravates Rheumatic
Symptoms.
39. Conditions Helped by
Minocycline List of conditions.
40. Microbes Vs.
Maladies Microbial co-factors of chronic illnesses:
41. Remarkable Case
Histories Infections, Inflammation, Recoveries.
42. Vitamin C (AA)
Relieves Coughing Fits. Whooping Coughs (1937)
43. Free Health Articles More Health Articles, Indexed