An exciting new area of research in antibiotic molecules is the study of the many metalloenzymes using both copper and zinc. It is well known that infections cause depletion of these metals, especially zinc, and that supplementation of zinc during acute infection stages along with vitamin C assists in shortening recovery times and reducing symptoms for colds.
The complex new field Metalloenzymes is beyond the scope of this website to describe, but may be the subject of further ongoing research in a few months. Keep looking to our website.
In the mean time here is an overview of MetaloEnzymes to set them in perspective.
Metals and near metals provide a + ionic bonding valence. They bond to atoms that share electrons, with a – ionic valence, like oxygen, sulphur, chlorine, fluorine, etc. Elements considered metallic are: Sodium Na; Calcium, Ca, Zinc, Zn;, copper, Cu, Magnesium, Mg; Manganese, Mn; Tin, Sn (Stannous); Silver, Ag;, Gold, Au; Aluminum, Al; Cadmium, Cd; Iron, Fe; Nickel, Ni; Chromium, Cr; Cobalt, Co; Selenium, Se; Mercury, Hg; Lead, Pb; Silicon, Si; Uranium; U.
Some metals are needed in trace amounts (Se) and at higher levels or certain forms are toxic: Mn, Se, Ni, Co, Cr, Hg, Pb, micro-Si. Some elements are problems in the metal handling and battery industries. Others are problems in the semiconductor industry. Some toxicity issues are related to the form of the colloidal and nano particles, like Si.
Other issues relate to a tight range in non-toxic tolerance or with build up without adequate or fast enough means to flush them from our system (Ni, Fe, Hg, Pb, Mn, Al, Si, Au, Sn…) Intake can be environmental: medical injections, medicines, contaminated or traces in supplements, water, mineral dust, contaminated factory working conditions, food intake (Hg, fish), smoke and air pollution.
Although all metals can be toxic in excess, the following can be considered particularly toxic: Mn, Au, Al, Ni, Hg, Cd, Cr, Pb, Se.
Aluminum is used as an adjuvant in vaccines. Recently the measures for exit rates for the Al in muscles have been proven to be much slower than assumed. This explains some of the vaccine related hyper immune observations and reopens the serious question of combined-vaccination safety due to aluminum toxicity. The significance of certain obscure medical papers in this regard have not been recognized by cognizant controlling authorities.
Even Iron, so essential to our oxygen transport, has a genetic subpopulation that cannot remove it; and so, for them, it can rise to toxic levels.
Radioactive SnF is used as a marker for bone infection radioisotope imagery, proving the affinity of this molecule to the site of the infection. CaF has a similar affinity and if taken in small amounts controls the infection and the growth of the bone calcifications.
Eating SnF (Stannous Fluoride) toothpaste has been reported as a helpful countermeasure for painful ostiomyelitis and bone calcification colonies of bacteria. The bone plaques attenuate the antibiotic penetration. In vitro biofilms attenuate antibiotic effectiveness by factors of hundreds to sometimes over 1000 times. For bone infections even more penetrating power is needed. Biofilms, plaques, granulomas and calcifications obviously invalidate the customary tetracycline antibiotic protocols dose levels by a wide margin, but to a degree so great that it renders useful antibiotics clinically useless without a boost. Serapeptase enzyme can provide a biofilm destroying factor that will potentiate the antibiotic.
It is also known that the tetracyclines beneficially change the activity of certain metalloenzymes. The codification into dosage limiting rulebooks of the low dose antibiotic protocols by doctrine to minimize antibiotics use has had many fatal effects and has let to much suffering. In such cases as ostiomyelitis restrictive treatment rules leave the patient without a prescribable level of antibiotic treatment. We see similar rules and custom against treating Lyme cases where the combined long term antibiotics are necessary but unconventional and doctors prescribing them are persecuted with false claims of malpractice.
Vitamin C has a chelating effect. Chelation combines metals into bound forms to permit its transport and removal around and from the body. Removal is certainly good for toxic metals like aluminum, mercury, chromium, cadmium, and uranium. After DHEA chelation it usually requires additional supplementation to replace lost Calcium, Zinc, Copper and Magnesium.
Zinc, copper, silver, and gold are associated with arthritic healing. They form a group in the periodic table of elements with an ionic bond valence of +2. Thus when they bond to other molecule parts they bond to atoms providing two electrons. Oxygen provides –2. With this +2 valence, they can bond in place of each other, provided there is space in a constructed enzyme molecule for them to fit. They will take these places depending on their relative concentrations, depletion and availability to in the enzyme under construction. Copper and zinc separately work against arthritic inflammation; but they may tend to work against each other in that increased zinc intake reduces the chance of copper availability in certain necessary reactions.
Certain metal atoms provide molecular stability for enzymes. In their absence, the molecule is unstable, may miss-fold into a pathogenic, dysfunctional shape or may just not work as effectively. The CoX-2 enzyme needs both Cu and Zn so if your immune system is making a lot of Cox-2, and you deplete, the immune functions may not work well or at all. It might be better, just to stop making defective enzymes if the metals needed are in short supply.
This leads to some nutritional folklore that may have some real dynamic metal deficiency causes. Reduce the metal deficiency and the immune system works more like it should; and both chronic and acute microbe resistance is higher.
The need for Zn and Cu is small, and the amount needed can be quite dynamic, with acute infections and immune reactions highly active, stores are quickly depleted. Both microbes and the host need metallic atoms for their enzymes. Chelation bonds to chelation agents and makes them partly unavailable.
It is well known that zinc depletion increases infection susceptibility leading to infection persistence.
Chelation can clear the deck of harmful microbe produced heavy metal (Hg, Cr, Pb, etc ) metalloenzymes components and also reduce the concentration to deplete the Cu and Zn Supplies, meaning beneficial metal ion supplements are instantly necessary.
Vitamin C also performs chelation; so if you take a lot of AA, you may need to take Cu and Zn supplements to avoid depletion levels.
Actions of metalloenzymes, production of defensive metalloenzymes, and pathogen generated metalloenzymes are now new regions of intense study. For example the possibility of the body’s building defective defensive enzymes in the absence of the needed metal atoms, and the presence of alternative metals needs to be understood.
Because there are thousands of metalloenzymes, just fully describing the following, for each metalloenzyme, is a tall task: