How
and Why Benign Low-Carb Ketosis + AA + Antibiotic
Fats + Nutrition
+ Anti-Inflammatories Work to Potentiate Antibiotic
Protocols:
In order to maximize the
kill percentage one needs a protocol that has multiple factors. The following
conceptual formulas illustrate how the combined protocol factors work in
theory.
The combined survival fraction is the product of the survival fractions of the several lethal
elements.
If kill percentage is K%,
define kill fraction as 0 < Kf <1 by K%/100.
Survival fraction: Sf = 1- Kf and Kf = 1- Sf.
Sf = (Sf1) x (Sf2)
x (Sf3) x (Sf4)
x….
Sf = (1-Kf1) x
(1-Kf2) x (1-Kf3)
x (1-Kf4) x….
By using multiple
antibiotics or adjuvants that have different principles of operation one can
multiply the effectiveness, and reduce the chance of developing antibiotic
resistance.
SfAntibiotics = (SfAntibiotic1)
x (SfAntibiotic2) x (SfAntibiotic3)
x (SfAntibiotic4) x ….. Combined
Antibiotics
SfAntibiotics = (1-KfAntibiotic1) x (1-KfAntibiotic2) x (1-KfAntibiotic3) x (1-KfAntibiotic4)
x …..
SfTotal = (SfAntibiotics)
x (SfAntibiotic-Fats) x (SfAA)
x (SfAnti-Inflammatories) x ….. Combined Protocol
SfTotal = (1-KfAntibiotics) x (1-KfAntibiotic-Fats)
x (1-KfAA) x (1-KfAnti-Inflammatories) x …..
S%Total = 100 x SfTotal
In order to minimize the survival percentage one uses more factors and tries to minimize each survival factor. Where replication occurs one tries to block the success of it, by targeting the factors leading to its success and reducing the odds by functional changes in the in vivo environment. One kill factor is Ketosis. John Ely describes the mechanism of glucose ascorbate antagonism (GAA) and Aggressive Glycemic Control (AGC). See note below: 14
Many other Kfs are Anti-microbial antibiotics. One is sugar or nutrient starvation. One is tryptophan starvation. 15 One is molecular spoofing. One is neutralizing a spreading factor. One is microbe <to/from> immune-cell signal blocking, by immuno-suppression. Several are a mineral antagonist, salt/silver/zinc. Many are eating anti microbial foods. Many are vitamin and nutritional deficiency related. Many are spices and herbs like olive and aloe vera. There will be more specific new ones that we will discover in the future, and old forgotten ones we will find in the various nations’ medical archives and learn how to implement.
AA (Ascorbic Acid = vitamin-C) Actions:
AA has two effects. One is to make it more difficult for the invaders to penetrate their target cells that they use for replication. The other acts inside the cell when ROS- oxidized AA kills the invaded cell with its compromised mitochondria. The effect of anti inflammatories is also multiple. One is to reduce the signaling of the microbe to the target immune cells that they would invade. This slows the replication. Another is to turn off the generation of the ROS that converts antioxidant AA to the oxidized for Dehydro AA (DHA). A third is to reduce the formation of plaques, granulomas, lesions, and calcium nodules that wall off and protect the microbes from the antibiotic.
Reactions are competitive and depend on
concentrations:
Chemical reactions depend on
the concentration of the various molecules.
The uptakes into cells for sugar and for DHA are competitive. If the sugar concentration is much greater
than that of AA then most of the uptake will be of sugar, feeding the microbe
cellular invaders. If the blood is
starved for sugar and DHA is present in high concentration, then the cells are
more likely to uptake the DHA. This is
to say that sugar interferes with the action of AA (= DHA) acting as a
initiator of invaded-cell death. So the
effectiveness of AA is improved by the low sugar Ketosis mode. It is worsened
by hypoglycemia and diabetes.
Similarly, the action of the
Antibiotic fats, the monoglycerides of the saturated tropical oils of the palm
plants are in proportion to their concentration. Since the nation’s diet prefers some fats above others, starving
the body of saturated palm fats reduces several natural antibiotics that have been
shown to help control both bacteria and viruses. COPD and bacteria caused plaque is likely to be made worse by too
little palmitic and lauric fatty acids. The attempt to reduce cholesterol is
misguided and it leads to labeling saturated fats as bad when the opposite is
true.
Jarish Herxheimer reaction (Herx):
Antibiotics kill cellular
microbes and create Jarish
Herxheimer reaction with reactive oxygen species ROS: H202
and NO. When active vitamin C (Ascorbic
Acid) molecule meets ROS molecule they react to disable the oxide and
this makes the oxide/oxidizing form of AA, called Dehydro AA (DHA). The
antioxidant, active form of AA neutralizes toxins of the Herx reaction and it
is a powerful histamine reducer. As ROS levels drop the histamine levels also
drop. “Large” amounts of AA are eaten
frequently, Start with 3-6+ grams as often as every two hours. Effective dosage for a Herx condition is
about 24 grams per day or more. Google
[Cathcart Titration to Bowel Tolerance].
How to tell the AA dosage you need:
If your gut does not get
loose, you need to take more AA. If gut
gets loose from eating the AA, you are taking too much or too often. If you are sick, with high levels of AA
intake, you should feel a reduction of the feelings of sickness. If sickness symptoms come back: pain, itch,
ague, etc, then you are out of AA and you need to eat more of it, immediately.
Since AA is stored in the lenses of the eyes the degree of focus accuracy may
fluctuate with systemic AA depletion.
Some persons know that when their eyes go out of focus, it indicates
that they are low on AA and need to eat more.
Microbes need sugar and body can work without much
sugar at all:
Normal body cells do not
need much sugar for energy; they can also use fats and proteins. But cancer
cells, microbes and infected cells need a lot of various microbe specific
sugars. AA does not get imported into
cells very much, but DHA goes into cells in very much greater amounts. But this
happens only if you are eating a lot of active AA to start with, and are not
eating much sugar.
Ketosis: how to induce it and test for it:
Benign ketosis (<15-30
grams of carbohydrates per day), see Atkins
Diet induction phase; it really lowers blood sugars. You can get ketone
test strips at any pharmacy to test if you are in the ketosis state. You may notice your breath smells like nail
polish remover. This is because you have a little acetone in your blood.
Acetone is in nail polish remover.
With ketosis: Liver stops
converting glucose to fats for storage. Liver switches to use fats and your cells’
mitochondria in the Krebs cycle burns the fats extracted from your blood. Lipid
HDL and LDL drop into the “normal” range.
Ketosis starves system of sugars.
Starches we eat are converted to sugars. So ketonically low carbs means
very low sugar in our blood.
Microbes invade cells: red and white blood cells;
epithelial and tissue cells; especially, they invade immune cells
chemically-signaled to kill and eat them.
Microbes in chronic,
persistent infections invade your epithelial cells and your immune cells, among
others, in certain organs that specific microbes have matching molecular
“hooks” to attach to. They use
hyaluronic acid Lysase, an enzyme that dissolves your cell walls, to penetrate
your cells and to inject their DNA or RNA into their target cells.
Inside invaded cells,
microbial genetic recipes cause the mitochondria to work differently and to
dysfunction. The microbe parts steal CoQ10 the energy oxidizer molecule and
sugar from your cells and you feel tired.
If you take more Co enzyme Q10 to make up for this you will feel almost
normal. The invaders need sugar and
CoQ10. But your cells can live by converting Fats and Proteins into the acetyl
CoA that is actually the fuel. The invaders --- bacteria,
viruses and fungal forms eventually replicate and kill the cell to get out. We
have seen striking pictures of their exit.
How Ketosis changes the cells’ functions:
Ketosis: In the absence of sugars,
DHA (oxidizing form of vitamin C) takes sugar’s place. This means that an
oxidizing molecule is imported and the microbe components try to use it as
fuel. This does not work and it kills the mitochondria and the infected cells
and the microbes that import it. The invaded cells’ microbes’ parts can work
with certain sugars, but cannot burn fat or protein as well. So the cell dies.
Cell Wall Deficient (CWD)
bacterial invaders and infected cells need lots of sugar. Soft drinks and
refined starches provide this. So see the Dr. Atkins diet materials for the low
carbohydrate diet’s induction stage rules to make sure you have somewhat less
than 15 to 30 grams of carbohydrates and are not eating any of the forbidden
food elements or eating too much.
You need enough DHA to act
as if it was sugar, and the cells normally metabolize a very large number of
grams of sugar. So you need to swallow the AA as if it were food. We usually do
not eat this much of vitamin C, by far. We should not get it as a food
component (like fruit juice) because it comes with too much sugar. But if you
think of pure AA as a sugar replacement food that you need, then 30 to 150 grams per day of AA is not much if
it were meat or candy.
CWD bacteria of various
species and strains prefer strain-specific sugar molecules. High Fructose Corn Sugar, (HFCS) is a mix of
several sugars and nourishes most varieties of CWD bacteria. There is a lot of
HFCS in soda drinks and in junk food.
Instead, your diet should be meats, fats, and natural fibrous vegetables
that have low sugar and starch content.
See the web for Atkins Diet
recipes and foods and how to limit the amounts you can eat. You must maintain a strict low carbohydrate
diet, to stay in ketosis mode. No
bread, potatoes, rice, pasta, breakfast foods, pastries, pies, donuts, corn,
carrots, yams, starchy beans, pasta, etc.
Perhaps your intake is about 500 calories/day. You can eat meat, fats,
un-breaded fish, shellfish, a little cheese, but no milk, buttermilk, cottage
cheese and ice cream. No condiments
that contain sugar. Read all the labels
and insure the number of grams of carbs is in the range for the Atkins diet
induction. You can stop the ketosis after your symptoms stop and you no
longer need to lose weight. When on Atkins diet, vitamin supplementation is
necessary.
How cells use energy:
Cells use a molecule called
ATP for energy. It is made in a recycling
reaction loop called the Krebs
cycle (Aka, citric acid cycle) that uses as its “food” a super
versatile enzyme, Acetyl-CoA,
made from Fats, Carbohydrates or Proteins by
a process called catabolism by mitochondria in cells. In the liver, with
ketosis ongoing the cells convert fats to glucose, the primary sugar the body
cells need. Too much dietary citric acid may promote bacterial growth.
Catabolism takes place in
cells’ mitochondria to convert fats and produce Acetyl-CoA. Then the Krebs cycle reactions use
Acetyl-CoA to make ATP, the cell energizer fuel that drives all the other
cells’ anabolic, energy-consuming reactions.
In the mitochondria, CoQ10 is the
oxidizer and Acetyl-CoA is the fuel and NADH (Coenzyme-1) is the helper enzyme,
so called spark plug. So in all cells
from muscles to brain, deficiency of CoQ10 will limit
the cells’ energy use. Your body needs
about 500 mg of CoQ10 per day, made by the mevalonate chemical pathway, where
cholesterol, CoQ10 and Heme is made.
When you get older you do
not make enough CoQ10 and may need supplements. If you have chronic intracellular infections, and we all do, then
you need CoQ10 supplements. The mevalonate pathway is blocked by statins.
Statins really starve the body’s cellular (nerve and muscle) regeneration
process by limiting cholesterol, CoQ10 and Heme,
a component of hemoglobin. Heme is used
in blood cells to transport oxygen throughout the body. Cholesterol is the
source of our sex hormones and is needed to keep nerves and muscles healthy and
to rebuild them as needed.
So if you starve the carbs,
then the Acetyl CoA fuel sources become fats and protein, and your cells
work. But microbes prefer non-glucose
sugars so ketosis starves them and they suck up DHA that is an oxidizer, not a
food. That further starves the cell and oxidizes the mitochondria. This kills
the invaders’ CWD L-forms and also kills the invaded cells that have ingested
microbial DNA. This blocks intra-cellular microbe replication. Because of their
sugar preferences certain microbes are more sensitive to ketosis than others.
So avoiding of HFCS and dietary sugars is best.
According to Mary Enig: The cause of heart disease is excess refined
vegetable oils and hydrogenated (Trans) fats; excess refined carbohydrates:
sugar and white flour; mineral deficiencies: magnesium, iodine, selenium;
deficiencies of natural unrefined vitamins: A-complex/B-complex/C; deficiencies
of antioxidants like vitamin E complex; and the disappearance of dietary
antimicrobial fats: animal fats (butter) and tropical oils: coconut, red palm
and palm kernel oils.
One could also add Lysine,
Proline and Carnitine deficiencies. AA
+ Lysine è Carnitine, needed for
muscle and tissue health. Lysine is
anti viral, especially for the human Herpesvirus family: HHV1&2 (HSV=cold
sores), CMV, EBV, H. zoster = Chicken pox and shingles, etc. L-arginine promotes HHV growth. See Pauling protocol
for heart disease. Excess
lysine and low arginine spoofs the microbes molecule building process.
Tropical
Oils contain: Saturated fatty acids---Lauric, Palmitic, Caprilyic,
Myristic; CoQ10; tocopherols and tocotrienols (vitamin E variants); and
antiviral vitamin A variants. Our packaged vitamins A & E are monomolecular
not a natural mix and do not have all the many process-dependent, unique shapes
we need. Natural, gently refined tropical oils are not heated excessively, not
bleached, not oxidized and not hydrogenated; they are made that way for the
nutrition trade. They contain the wide spectrum of molecular shapes you may
need in ways that go beyond our simplistic theoretical knowledge of their
actions.
The saturated fatty acids do not oxidize easily or turn rancid
rapidly. Rancid fats are toxic. If rancid or hydrogenated (trans) fats were
used to make cholesterol some resultant molecules produced would be toxic to
nerves. Statins cause cholesterol starvation, opening the way for toxic oil
variant molecules to take the place of the missing cholesterol, leading to
nerve and muscle cell dysfunctions and cell replacement molecule errors that
shorten our life by increasing our aging rate.
Tropical oils are very
readily used as fuel, they pass the blood brain barrier, and they dissolve the
CWD membrane to kill CWD forms and viruses system wide. Monoglyceride forms of Lauric, Caprilyic,
Palmitic, Myristic are antimicrobial. Lauric and Palmitic are most essential to
systemic anti microbial health. Daily 2
to 3 tablespoons of tropical fats: coconut, red palm oil, and palm kernel oil
or a mix of the three to get all the natural nutrients with the widest range in
molecular shapes. We will use the active shapes and burn the others. A case
history below shows Alzheimer’s improvements.
Antiviral Omega 3 oils are also
essential to health. They come from fish and cod liver oil, along with vitamin
A.
Herx Management:
Because this protocol
depends on ROS to convert AA to DHA, totally suppressing the antibiotic
initiated Herx reactions by use of immune-suppressing drugs defeats the purpose
of generating DHA to kill infected cells.
However for very severe inflammatory conditions, the following measures
can help to reduce the severity of the Herx reactions. Cortisone and prednisone can reduce
inflammation, granulomas, scleroses, lesions, plaques and microbe (viral)
replication. Benicar, an angiotensin release blocker (ARB) can block the
cytokine cascade inflammation flare and allow increased antibiotic dosages. TNF
blockers also stop inflammation. Granuloma formation walls off TB bacteria and
protects them from antibiotics. So anti inflammatories functionally and
statistically potentiate antibiotic actions.
During the Ketonic protocol,
eating patient specific allergy-producing foods, like peanuts or other foods
known to turn on immune system may be used if the Herx reaction does not rise
to the level needed to convert AA to DHA. An experienced physician who will
work closely with you over the period of administration, best can handle
managing the proper balance of inflammation and immune suppression. Fire and
forget is not the mode of treatment. In the absence of the physician, every
hour, you have to learn to listen to the feelings of pain, tingling and
irritation to sense the action of the foods and medicines and learn which
combinations improve things and which changes make things worse.
Time cycling the antibiotics:
Time cycling the antibiotic
is useful because the microbes CWD forms switch forms within minutes in vitro
and in vivo to protect themselves from the antibiotic. Lyme CWD forms roll up in tight balls, then
unroll later. If a two-day on/off/on/off antibiotic cycle is used each cycle reduces
the population by an assumed 30%, after 20 cycles (40 days), the Sf20-cycles
= 1/(1-.3)20 = .0006.
When this is combined with other protocol elements like Lauric acid to attack microbes’ membranes and palmitic in the lungs to reduce immune signaling, the total reduction can be dramatic.
Immune suppression and antibiotics work well together because the sclerotic plaques wall off the microbes and protect them. The immune suppression increases the kill percentages and speeds. Prednisone or TNF blockers alone used as an antibiotic adjuvant with conventional TB antibiotics showed a reduction of relapse rate from ~30% to ~2%.
A side comment on
histamine:
Antihistamines might seem to be helpful in severe Herx reactions, but with the high AA blood levels of this protocol, there should be very little histamine produced. High histamine is a result of the combination of AA depletion and NOS, not a cause of it. With high ROS and not on the high AA protocol, toxins and allergies and acute infections cause AA depletion. When AA levels get below .7 mg/100 ml the histamine levels start to increase exponentially. See the graph in this hyperlink. Histamine is toxic in high levels. Histamine food poisoning (e.g, from decomposed tuna or certain bacteria in cheese) is evidenced by a red skin flush over most of the upper body.
Olive leaf extract is a
broad spectrum antimicrobial. When we were patients of Dr. A. Robert
Franco, he included this in his nutritive protocol. Here
is an example of how it works.
Other protocol adjuvants can
be found in food, especially in ethnic recipes and condiments. See our page on Antiviral
Foods. You may find additional adjuvants to improve kill rates among
the antiviral foods, spices and herbs which you can eat regularly in normal
food portions.
Tropical saturated oils are protocol adjuvants:
POPG, a lung surfactant
derived from palmitic acid (butter and palm oil) combined with palmitic acid is
an ideal surface tension reducer, making breathing easier. It also interferes with the inflammation
signaling between microbes (bacteria like mycoplasma pneumonia and
viruses like RSV) and immune cells. See our discussion of COPD
countermeasures.
Since the microbes are
equipped to invade the immune and epithelial cells, if the immune cells attack
the microbe, they will be invaded and turned into replication factories, so blocking
the signaling blocks the replication and granuloma formation. This may be how prednisone blocks
replication for Coxsackie’s and other viruses.
AA’s proven action blocking
hyaluronic acid lysase enzyme the, bacterial penetrating/spreading factor reduces
cell invasion; ROS +AA => DHA which
kills the invaded cells. Killed cells release toxins contributing to the Herx
reaction inflammation, making more ROS and requiring increased AA intake.
Plaque and Biofilm antibiotic resistance:
Eating SnF2 (Stannous Fluoride)
toothpaste has been reported as a countermeasure for painful ostiomyelitis and
bone calcification spurs, colonies of bacteria. The bone plaques attenuate the
antibiotic penetration. In vitro biofilms
attenuate antibiotic effectiveness by factors of hundreds to sometimes over
1000 times. For bone infections even
more antibiotic penetrating power is needed.
Biofilms, plaques, granulomas and calcifications
obviously invalidate the customary tetracycline antibiotic protocols dose
levels by a wide margin, but to a degree so great that it renders
otherwise-useful antibiotics clinically useless without a boost.
Serapeptase and bromelain enzymes can provide a
biofilm destroying factor that will potentiate the antibiotic by destroying the
colonies’ protective barrier. Serapeptase enzyme helps COPD and may be useful
for other protocols.
Hyperglycemia and Inducing Relapses:
By using a multiple factored
attack on invading microbes one can increase the kill fraction and reduce the
microbes’ survival. When the treatment is stopped, hypoglycemia may return; a
lower level relapse may result, but re-treating in the same manner can usually
be successful. If relapse recovery is difficult, different antibiotics will
target other microbes that the first did not kill.
Hyperglycemia and diabetes
defeat the AA factor in the protocol: both failing to attack the microbes in
the invaded cells and disabling the effect of the AA reducing the bacterial
spreading factor. Dietary sugar provides nutrition for the bacteria.
Multi-sugars like high fructose corn sweetener (HFCS) found in sodas
condiments, many sweet pastries are the worst kind. They contain many different
sugars matching the different molecule shape-dependencies of the various
microbe strains.
Hypoglycemia and ketosis
starve the microbes. In the diabetic condition benign ketosis with fat
metabolism needs to be managed carefully. Close coordination with your
physician is an important factor, but the patient should carefully monitor his
feelings, sensations, food intake, and exercise levels in order to permit him
to stabilize his sugar state to the region that is unfavorable to the
microbes. The Atkins Diet books in the
references below are important guides to low sugar recipes.
In one case a glass of
orange juice caused a sensation of activity in the painful joint bone area of
the infection. A second glass of orange juice, with all its sugar, introduced a
permanent sensation and a relapse. Eating peanuts during the treatment was used
to intensify the Herx. Eating
honey-coated peanuts without the antibiotic and the AA was enough to induce a
strong relapse. A number of Treat-Relapse cycles were induced, with decreasing
infection intensity as successive survival fractions decreased after each
ketosis/starvation stage.
It is controversial whether
this protocol can permanently eliminate a really persistent poly-stage microbe
like C. pneumonia, Borellia,
Babesia, etc. It is our opinion that it will not, and our experience is
that a multi factored treatment regimen must be repeated every year or so,
prophylactically, to suppress the microbial rebellions that periodically occur.
Gut Dysbiosis is a result of antibiotic protocols:
The gut’s microbiome is disrupted by antibiotic anti-bacterial protocols. It is essential to frequently repopulate the gut with new lactose fermenting bacteria. Shredded cabbage can be fermented at room temperature with a yogurt culture of known strains and purity. After fermenting for several days move culture to refrigerator to keep it for longer time. See our website below for how to do this. Eating the fermented sauerkraut several times a week keeps your gut healthy, preventing acquired lactose intolerance.
Gut Infections: HIV/AIDS; Measles/ASD; Yersinia entercolitica/Ankylosing
Spondylitis; Unknown-gut-infection/Lower back pain.
HIV recovery or reversal has been multiply-reported, based on coconut oil and/or vinegar, taken incessantly, as a drug, multiple times a day. MMR live-vaccine sometimes causes chronic measles-vaccine-virus-strain gut-infection. Persistent Autism related (ASD) neural inflammation might be reduced if this gut infection is eliminated. High amounts of Vitamin A or cod liver oil is antiviral, and has shown some success. Add coconut oil.
Cleaning out the gut, sterilizing with vinegar and water, Rebooting the gut flora and repopulating gut with probiotics, buttermilk, and yogurt should help by revising the gut ecology. Maintain new ecology with daily coconut and palm oils and refresh probiotics with yogurt cultures and live yogurt cultured sauerkraut.
For IBS, a cabbage fermented culture was found to help. See: www.rejuvenative.com/catalog_one.htm or find similar products in health stores. Buy one use for starter and make your own fermentation with raw cabbage, lightly blended and plain yogurt with known cultures. (Ref 17)
Back pain with calcifications and bone spurs are signs of bone periosteal infections of the bone lining surface cells. This protocol with tetracyclines like OxyTetracycline worked successfully. Fluoride, either sodium, calcium or stannous fluoride worked to suppress the growth of the calcifications. In theory stannous fluoride, an ingredient in some tooth pastes should work best. But homeopathic calcium fluoride has been successful both for humans and horses.
Back pain was reduced or eliminated by rebooting the gut along with the following: Fluoride, either sodium, calcium or stannous fluoride worked to suppress the growth of the calcifications. In theory stannous fluoride, an ingredient in some toothpastes should work best. But homeopathic calcium fluoride has been successful both for humans and horses.
Back pain with calcifications and bone spurs are signs of bone periosteal infections of the bone lining surface cells. This protocol with tetracyclines like OxyTetracycline worked successfully. Stannous fluoride would be an adjuvant to the therapy.
Case Histories:
Ketosis plus vitamin C
(AA) is an adjuvant to the Tetracycline-antibiotic protocol. Combine Klenner's
AA and Rheumatoid Arthritis” The Infection Connection, Appendix 2
tetracycline/minocycline protocol. Benign ketosis is induced by drastic
reduction of carbohydrate intake to < 12 grams of carbohydrates per day.
[See Dr. Atkins’ diet induction stage]
The liver shifts from fat storage mode to fat extraction mode and brown fats are catabolized to acetyl CoA to feed the Krebs (citric acid) cycle where ATP is made to feed energy to all the body cells. Body-cell sugar use shuts down. Hypo-glycemic condition stops in ketosis mode.
Microbes and viruses are
sugar dependent, so are drastically starved. ROS of the sickness oxidizes the
AA to the DHA form. Microbes, microbe-infected body and cancer cells need sugar
and ingest oxidized Dehydro Ascorbic Acid (DHA) instead. Inside the
microbes and the infected cells the DHA oxidizes the cells' mitochondria and
induces apoptosis (cell death).
AA levels of about 28 grams
per day were used in one case history on our website in addition to the
Appendix 2 tetracycline protocol to reverse (cure) a severe painful bone-joint resident
infection of unknown origin in a period of 4 days. Peanuts were used as an
adjuvant to enhance the ROS. Stannous fluoride was used to attack the
calcifications.
Post treatment, eating
honey-covered peanuts was enough to re-trigger the pain locus. The protocol was
repeated successfully several times when relapse was induced by the sugar in
orange juice. The periods of remission extended and severity of relapse
decreased with each repetition of the ketosis and the combined protocols.
Comment: Add the nutrition in the next case history to further improve the gut microbiome.
A Remarkable Success: Reversal by Ketosis diet and
Coconut oil:
Alzheimer’s
Disease Case History
“…Steve, first showed signs of Alzheimer's disease. [In 2000] After his
deterioration accelerated in 2004, Dr. Newport began avidly researching ways to
keep him functional for as long as possible.
“…she [found] research showing that medium-chain
fatty acids, which act like an alternative fuel in the insulin-deficient
Alzheimer's brain, can sometimes reverse or at least stabilize the disease.
When she gave Steve about 2 tablespoons of coconut oil (a source of these fats)
at breakfast before a memory test that he had previously failed, Steve
miraculously passed the test. Since then, Steve continues to maintain
improvement while taking daily doses of coconut oil and MCT (medium-chain
triglyceride) oil with meals.
“… readily available fatty acids in foods that may reverse
the ravages of this dreaded disease. Changes in loved ones may take many forms,
including improved memory, return of personality, resumption of activities and
social interaction, and relief from certain physical symptoms.
“Because ketone
esters, a synthesized form of these powerful fatty acids, work faster and
more comprehensively than fatty acids in foods, Dr. Newport has become an
ardent advocate for ketone ester research, with FDA approval her final goal.
“..this book that summarizes Dr. Newport's research and Steve's reprieve, the importance of medium-chain fatty acids, and how Alzheimer's patients can make the transition to a healthy diet rich in these vital fats.”
Ketone ester vs Parkinson’s Trial: NCT01364545, Enrolling at Oxford June, 2011.
Comment: Lauric acid in coconut oil is antimicrobial
systemically. It is antiviral in the gut. It is anti-arterial sclerosis too.
Add to Coconut oil CoQ10 which increases blood flow to the brain. Take Red Palm
oil and palm kernel oil, rich in alternate forms of Vitamins A and E. Vitamin A
is antiviral. Palmitic acid in palm and coconut oil is also found in butter.
Palmitic acid is precursor for POPG1
a lung surfactant that reduces COPD microbes (both bacteria and virus) pathogenic
action. POPG reduces the signaling by which the microbes can attract their
target immune cells to invade.
Thus, immune-suppression minimizes
walled colony formation and plaques, and facilitates antibiotic penetration.
This potentates antibiotic action, increases kill rates, decreases relapse
percentages from ~40% to 2% in case of TB bacteria treatment without any
coconut oil adjuvant to the treatment.
Alzheimers and Parkinson’s cofactors are likely to be at least some of the following microbes:
B.b, C.pn, Bartonella, Babesia, All susceptible to antibiotic, ketone, tropic oils, Multifactor therapy
It is worth combining both this case history and the previous case history’s methods. Multiple adjuvants should work as shown in the mathematical formulas (above) to improve successful outcomes.
Dr.
Atkins’ Vita-Nutrient Solution: Nature’s Answer to Drugs by Robert Atkins, M.D. Simon and Schuster, 1998,
1999, 407 pages. Book-Finder
Dr.
Atkins has compiled a guide to nutrition for the person who is ill. This
authoritative and insightful compendium of vitamins, minerals, herbs, amino acids,
and their restorative powers tells how they help the patient with serious
medical conditions. Cancer, diabetes, MS, heart disease, arthritis, autism,
vision problems, dental problems, skin conditions, CFS, fibromyalgia,
autoimmune diseases, allergies, osteoporosis, scleroderma, urinary tract
infections, pulmonary conditions, intestinal problems, men’s and women’s
health, etc. Dr. Poehlmann has recently been reading this book carefully
and it is highly recommended. We plan to compile a better index to this
wonderful book and publish it on our website.
Dr.
Atkins’ Nutrition Breakthrough: How to Treat Your Medical Condition Without
Drugs by
Robert Atkins, M.D. Bantam Books, 1982-86, 380 pages. Book-Finder Dr. Atkins was a cardiologist who
embraced “natural,” complementary medicine, dietary modification, and nutrition
to treat molecular imbalances that cause poor resistance to microbial
colonization. His low sugar/low carbohydrate diet, supplemented with
appropriate vitamins is an effective way to control hyper/hypo-glycemia, bad
cholesterol, yeast/fungal infections, and many specific chronic illnesses. His
diet is based on the idea that all calories are not the same among fats,
carbohydrates, and proteins. Each molecule has its own utilization
effectiveness number that indicates how well its calories are used or not used
as fuel or converted to body fat.
Dr.
Atkins: New Diet Revolution by Robert Atkins, Harper, 2001, 560 pages. Book-Finder Our personal
experience with his diet has confirmed several of his important claims. We
found that a reduction in refined sugar and carbohydrates led to near
elimination of yeast/fungal related hyperglycemic symptoms, including
neuropathy, and also led to increased resistance to other infections.
This is the guide to how to induce the benign ketosis state of metabolism in
your body.
The
No-Grain Diet by Alison Rose
Levy and Joseph Mercola, Plume,
2004, 320 Pages Book-Finder The No-Grain Diet: Conquer Carbohydrate Addiction and
Stay Slim for Life. For all of us refined carbs from grains provide many
delicious but harmful treats that replace nutritious foods we should eat. Wheat
can contribute to celiac allergies for some of us. Gluten allergies complicate
some persons’ Autism inflammation. No-grains diet is organic vegetables and
quality protein (avoid ocean fish), with limited fruits and absolutely no
simple carbs. Refined grains are basically deadly and addictive.
|
Antibiotic |
Spectrum of
Activity and Resistance Pattern |
Comments |
|
Penicillins
|
|
|
|
Amoxicillin |
No
activity against atypical and beta-lactamase-producing bacteria |
Resistance
limits use |
|
Amoxicillin-clavulanate |
Activity
against major pathogens |
More
costly |
|
Cephalosporins
|
|
|
|
General |
Activity
against major pathogens |
Alternative
to beta-lactam agents and generally as effective |
|
Second
Generation |
|
|
|
Cefaclor |
Can
be destroyed by Haemophilus influenzae and Moraxella catarrhalis
enzymes |
Associated
with failure in patients with severe disease |
|
Cefprozil |
Moderate
H. influenzae activity |
|
|
Cefuroxime |
|
|
|
Loracarbef |
Moderate
H. influenzae activity |
|
|
Third
Generation |
|
|
|
Cefdinir |
|
|
|
Cefibuten |
No
activity against Staphylococcus aureus |
Poor
gram-positive activity limits use |
|
Cefixime |
Poor
activity against S. aureus |
|
|
Cefpodoxime |
|
|
|
Macrolides
|
|
Active against Mycobacterium avium. M. kansaii |
|
General |
Macrolide
resistance concerning with S. pneumoniae |
|
|
Azithromycin |
Greatest
activity against H. influenzae |
Short
course of 3-5 days may be used. Long term may cause hearing loss. |
|
Clarithromycin |
Greatest
activity against S. pneumoniae |
Alteration
of taste may be an issue with bid dosing |
|
Erythromycin |
Poor
activity against H. influenzae |
Limited
spectrum of activity |
|
Tetracyclines
|
|
|
|
Doxycycline |
Covers
major pathogens and atypical organisms S. pneumoniae resistance
is common |
Maybe
an alternative to quinolones and macrolides when atypical coverage is needed.
See PMID: 21977068 |
|
Minocycline |
Similar
to doxycycline |
|
|
Tetracycline |
Limited
activity against major pathogens |
Limited
spectrum of activity |
|
Fluoroquinolones
|
|
|
|
General |
Active
against all major pathogens, atypical pathogens, Enterobacteriaceae,
and Pseudomonas aeruginosa |
|
|
Ciprofloxacin |
Least
active against S. pneumoniae |
Use
if P. aeruginosa coverage is required |
|
Gatifloxacin |
Enhanced
gram-positive activity |
|
|
Levofloxacin |
|
|
|
Moxifloxacin |
Greatest
activity against S. pneumoniae |
|
|
Other
|
|
|
|
Trimethoprim-sulfamethoxazole |
Covers
major pathogens |
Resistance
limits use |
“The properties that determine the anti-infective action of
lipids are related to their structure, e.g., monoglycerides, free fatty acids.
The monoglycerides are active; diglycerides and triglycerides are inactive. Of
the saturated fatty acids, lauric acid(C-12) has greater antiviral activity than
caprylic acid (C-8), capric acid (C-10) or myristic acid (C-14).
“In general, it is reported that the fatty acids and
monoglycerides produce their killing/inactivating effect by lysing the plasma
membrane lipid bilayer.
“The antiviral action attributed to monolaurin is that of solubilising
the lipids and phospholipids in the envelope of the virus, causing the
disintegration of the virus envelope
However,
there is evidence from recent studies that one antimicrobial effect in bacteria
is related to monolaurin's interference with signal transduction (Projan et
al., 1994), and another antimicrobial effect in viruses is due to lauric acid's
interference with virus assembly and viral maturation (Hornung et al., 1994).”
Palmitic(C:16) is also antibacterial and reduces signal transduction.
Dr Frederick Klenner: (1953) Early Clinical Usage of Vitamin C. Quote:
“Our interest with vitamin C against the virus
organism began ten years ago in a modest rural home. Here a patient who was
receiving symptomatic treatment for virus pneumonia had suddenly developed
cyanosis.
“He refused hospitalization for supportive
oxygen therapy. X-Ray had been considered because of its dubious value and
because the nearest department equipped to give such treatment was 69 miles
distant.
“Two grams of vitamin C was given
intramuscularly with the hope that the anaerobic condition existing in the
tissues would be relieved by the catalytic action of vitamin C acting as a gas
transport aid in cellular respiration.
“This was an old idea; the important factor
being that it worked. Within 30 minutes after giving the drug (which was
carried in my medical bag for the treatment of diarrhea in children) the
characteristic breathing and slate-like color had cleared.
“Returning six hours later, at eight in the
evening, the patient was found sitting over the edge of his bed enjoying a late
dinner. Strangely enough his fever was three degrees less than it was at 2 P.M.
that same afternoon.
“This sudden change in the condition of the
patient led us to suspect that vitamin C was playing a role of far greater
significance than that of a simple respiratory catalyst.
“A second injection of one gram of vitamin C
was administered, by the same route, on this visit and then subsequently at six
hour intervals for the next three days.
“This patient was clinically
well after 36 hours of chemotherapy. From this casual observation we have been
able to assemble sufficient clinical evidence that prove unequivocally that
vitamin C is the antibiotic of choice in the handling of all types of virus
diseases. Furthermore it is a major adjuvant in the treatment of at other
infectious diseases.
With a great deal of
enthusiasm we decided to try its effectiveness with all of the childhood
diseases. Measles was singled out more so than the others because of the
knowledge that it was a small virus like the one causing poliomyelitis.
It was reasonable to assume
that if measles could be controlled then Poliomyelitis, too, would have a drug
that could prevent as well as cure the disease.
The use of vitamin C in
measles proved to be medical curiosity. For the first time a virus infection
could be handled as if it were a dog on a leash.
In the Spring of 1948 measles
was running in epidemic proportions in this section of the country. Our first
act, then, was to have our own little daughters play with children known to be
in the “contagious phase.” When the syndrome of fever redness of the eyes and
throat, catarrh, spasmodic bronchial cough and Koplik spots had developed and
the children were obviously sick, vitamin C was started.
If the drug was then
discontinued for a similar period (48 hours) the above syndrome returned. We
observed this of and on picture for thirty days at which time the drug (vitamin
C) was given 1000 mg every 2 hours around the clock for four days.
This time the picture cleared
and did not return. These little girls did not develop the measles rash during
the above experiment and although exposed many times since still maintain this
“immunity.”
Late cases were given the
vitamin by needle. The results proved to be even more dramatic. Given by
injection the same complete control of the measles syndrome was in evidence a
24 and 36 hour periods, depending entirely on the amount employed and the
frequency of the administration.
Aborting of these cases before
the development of the rash apparently gives no interference to the development
of immunity. Recent progress on the rapidity of growth (a development) of the
virus bodies by means of the electronic microscope makes intelligent the
failure experienced by earlier workers when employing vitamin C on the virus
organism (or bodies).
Unless the virus is
completely destroyed, as demonstrated in the experiments with the virus using
measles, the infection will again manifest itself after a short incubation period.
Small, single daily doses do not even modify the course of the infection.”
Note Recent PubMed article states: “The
blood half life of vitamin C is 30 minutes” to deplete to ½ with no intake.
Also see: http://www.townsendletter.com/Klenner/KlennerProtocol_forMS.pdf Multiple sclerosis (MS) and (MG) myasthenia gravis recovery nutritional guidelines for vitamin dependencies where a much higher than normal dosage is therapeutic if given over a long enough time of several years.
Other References:
“Glycemic Control. Almost 2000 years ago in the
time of Galen, it was observed that tumors grew poorly or not at all in
underfed (i.e., low BG) animals. In 1972, Ely deduced and related to Linus
Pauling a theoretical reason why clinical trials of AA against colds and cancer
might fail because of the high BG levels in the affluent nations. The theory is
relevant to aging, birth defects, cancer, cardiovascular disease (cvd),
infections, etc. It is called the "Glucose Ascorbate Antagonism"
(GAA) and is important in the "small" dose range (AA~10g/d or less).
It says that certain cell types such as leukocyte and fetal have intracellular
AA levels that are "pumped up" largely by insulin ~50 times higher
than serum AA levels in the surrounding blood. This occurs if BG is in the low
range that was normal until the 1900's and is still seen today where the
primitive (unrefined) diet prevails, i.e., 50-90 mg% two hours postprandial
(Ely 1996; Chatterjee and Bannerjee, 1979, Table1). The high AA levels in such
cells are needed to drive the HMP shunt to supply hydrogen peroxide for
phagocytosis and ribose for mitosis. "Modest" BG elevations (~50%,
common after western diet meals) competitively inhibit insulin-mediated active
transport of AA into these cells, resulting in low intracellular AA levels, low
HMP shunt, and cell dysfunction (i.e., leukocytes don't attack tumors or
pathogens, fetal cells divide too slowly, etc.); this is the
"Antagonism". It has been suggested that low BG may also cause the
removal of negatively charged sialic acid (a 9-carbon sugar) from tumors that
otherwise repel negatively charged T-cells. A principal cause of cvd is
hyperglycemia which reduces AA to scorbutic levels in vascular intimal cells
(see pp. 52-55 in Pauling 1987). The GAA theory gives rise naturally to
"Aggressive Glycemic Control" (AGC) as a modality that, properly
used, appears to have much value against many disorders as stated above.”
“Some Hypoglycemic Limits. Of course, one doesn't
want BG too low because cortisol rises and can damage cmi by its lympholytic
effects. Also, humans become unconscious (not necessarily harmful) below 40
mg%. Brain damage is reported to occur below 20 mg%. However, cmi is reported
to work well down to ca 10 mg%. Cancer, infections and other diseases (cvd,
etc) have much lower incidence with adequate AA and BG 50-90 mg%. In
insulin-coma therapy, formerly used in the treatment of psychiatric patients,
blood glucose was maintained circa 30 mg%. Incidental to this, remissions from
cancer were reported to occur in patients whose incurable malignancies were
unknown to the psychiatrist at the time of treatment (Koroljow, 1962). A more
practical AGC might maintain BG at 50-60 mg% with insulin or Orinase (a
non-halogenated oral hypoglycemic). Trivalent chromium deficiency in US soil
and diet causes impaired glucose tolerance, high BG, and disease (Ely, 1996).”
POPG Chemistry: Related to COPD and Palmitic Acid as
Lung surfactant that suppresses microbe-immune signaling
Gut Health:
Gut
Health Case Histories:
Fermenting Cabbage to Sauerkraut to Cure Gut Dysbiosis and Lactose Intolerance.
Contains a recipe. For recovery from gut dysbiosis after antibiotic treatment of Giardia infection.
May be helpful
for Crohn’s disease, gut dysbiosis, and lower back pain and ankylosing
Spondylosis.
Emu Oil, is high
in oleic acid. Acts as a transport mechanism for medications into the body from
the skin. It unclogs pores and is not irritating. It is anti-inflammatory and
bacteria & fungus suppressing. It is used as a massage oil that transports
to inside joints where it’s bacteriostatic and antifungal effects can kill
off joint and back microbial colonies. It reduces inflammatory
pain, swelling and stiffness in joints, and reduces pain of injuries and
strains. It is stable, does not spoil and does not support microbe growth on
the shelf.
Case Histories at HerbalHealer.com:
These case histories show
emu oil is effective in reducing toe nail fungus, diabetic arthritis pain
relief, sore & cracking skin, heals fungal-produced skin dryness, heals
even severe diaper rash, normalizes chapped and scaling skin, eczema, improves
psoriasis. Relieves minor back pain, bulging disks, tendonitis, and carpal-tunnel
pain.
DMSO DiMethyl Sulfoxide DMSO is a
transport medium.
Warning: DMSO combined with
oxygen therapies can be lethal. Metabolites of DMSO are nerve toxins.
DMSO is useful for sprained joints and to transport beneficial oils into joint areas. We used Methyl Salicylate (Oil of wintergreen) to treat tendon synovitis, carpal tunnel syndrome of the feet and ankles. It facilitates transport of both oil and water based chemicals through the skin into an inflamed part of the body and helps the swollen area water removal. Medically pure DMSO is available in health stores in the united states and on the internet.
