KK
COPD
and Anti Infection Countermeasures: COPDcountermeasures.htm
Lack of certain oil-derived precursor components restricts hormone, and/or enzyme action, and also can lead to immune system up disregulation. Dietary propaganda has classified several essential precursor oils as harmful when they are not.
Mary Enig described some effects of the U.S. diet: low intake of tropical oils causes susceptibilities to microbes, e.g. HIV, RSV and Mycoplasma pneumonia, Chlamydia pneumonia, etc, contributing factors in COPD flares.
She also has noted neglected papers that report insufficient butter intake in the presence of high amounts of canola oil (Omega3) has lead to heart lesions. Rats died on canola diet with no palmitic acid intake in two tests one in Japan and one in Canada. Saturated fat molecules are precursor molecules for essential molecules made in the body. Tropical oils have been given a bum rap. Oil intake needs balance, which is missing. (Refs: 7-12)
Restriction or elimination of essential tropical
oil precursors in our diet is contributing to gut and respiratory dysbiosis. Lauric acid in coconut oil converts to
monolaurin (ML) in the gut. ML dissolves gut microbe’s lipid coatings and
interferes with their ability to bind to target cells. (Ref: 3) A surfactant, sodium lauryl sulfate, a
common detergent, might play a similar role, but simple monolaurin formed in
the gut is the safer alternative.
Gut Infections: HIV/AIDS,
Measles/ASD, Yersinia entercolitica/Ankylosing Spondylitis Unk/lower
back pain.
HIV recovery or reversal has been multiply-reported based on coconut oil and/or vinegar, taken incessantly, as a drug, multiple times a day. MMR live-vaccine sometimes causes chronic measles gut-infection. Autism (ASD) neural inflammation might be reduced if this infection is eliminated. High amounts of Vitamin A or cod liver oil is antiviral.
Cleaning out the gut, sterilizing with vinegar and water, Rebooting the gut flora and repopulating gut with probiotics, buttermilk, and yogurt should help by revising the gut ecology. Maintain new ecology with daily coconut and palm oils and refresh probiotics with yogurt cultures and live yogurt cultured sauerkraut. For IBS, a cabbage fermented culture was found to help. See: www.rejuvenative.com/catalog_one.htm or find similar products in health stores. Buy one use for starter and make your own fermentation with raw cabbage, lightly blended and yogurt with known cultures. (Ref 17)
COPD treatment using diet changes, enzymes, and POPG
aerosol.
A palm oil derivative, Palmitoyl-oleoyl-phosphatidyl-glycerol (POPG), a phospholipid surfactant, normally found in the lungs, plays a complex beneficial role in binding to respiratory synclinal virus (RSV), to Mycoplasma pneumoniae, and likely to other COPD bacterial components. POPG interferes with the respiratory microbes’ ability to invade epithelial cells, to replicate, and to form plaques/biofilms. It also interferes with RSV’s ability to attach to molecules that stimulate immune reactivity. (Refs: 1,2) POPG also reduces the surface tension and viscosity of lung fluid and makes it easier to breathe.
A dietary intake low in
palm-derived oils, precursors to POPG, is likely to predispose to COPD, by
insufficiently blocking microbial ligand functions. Butter contains lots of
palmitic acid and small daily amounts are essential.
Specific recommendations:
· Add butter, palm, palm kernel, and coconut oils to the daily diet in amounts of several tablespoons, total. Use these oils in place of oils from peanut, rapeseed = canola, corn, soybeans, cottonseed, etc. Vinegar taken daily has a similar microbe coat-dissolving effect in the gut. These ingredients can be added appropriately to recipes or taken separately as a supplement. Extra virgin olive oil is antimicrobial, as is olive leaf extract.
· POPG is available as a powder in small amounts (100 milligrams) but is expensive. It would be needed in micrograms in an inhaler (~50ug/ml) It could be liquefied and packaged in a spray bottle by a compounding pharmacy. Just
· The enzyme Serapeptase is known to lyse fibrin, to liquefy mucus, and to destroy respiratory bacterial biofilms. It should be taken as needed to reduce congestion and facilitate breathing. It liquefies phlegm.
· Ascorbic acid 2-3 grams every 2 hours 12x /day for 4 days controlled/eradicated wild measles infections. (Klenner-13)
· See: Vitamin C (AA) Pharmacokinetics and Pharmacodynamics.
· Gut dysbiosis implies a greater need for vitamins: E.g., Vitamin C, B12, A, See Klenner on Myasthenia Gravis for additional nutrition notes for difficult vitamin dependencies where very high levels are required by some patients.
· Vitamin A from cod liver oil has reversed ASD (see G Alpha protein) for a tunnel-blindness genetically predisposed subpopulation. Megson Vitamin A is antiviral. Coconut and palm oils if gently refined contain CoQ10, Vitamin E complex, and Vitamin A complex molecules including multiple variants of tocopherols and tocotrienols. This mix is a naturally nutritious feed stock for our chemical pathways to make essential cholesterol molecules including both metabolic and steroid hormones.
· Beware statins that block the mevalonate pathway that produces essential cholesterol and CoQ10, leading to neural and muscular degeneration (Rhabdomyolysis), pain and peripheral neuropathy.
· Tetracycline antibiotics: Minocycline, Doxycycline, and OxyTetracycline work against Mycoplasma pneumonia and other “atypical pneumonia” bacteria in COPD. See our book Chapter 2 and see the Road Back Foundation.
· For nutrition websites see references at our website.
·
See: www.cpnhelp.org/home
for help with combined antibiotic protocols (CAP) for persistent Chlamydia
pneumonia.
|
Antibiotic |
Spectrum of Activity and
Resistance Pattern |
Comments |
|
Penicillins |
|
|
|
Amoxicillin |
No activity against atypical and beta-lactamase-producing
bacteria |
Resistance limits use |
|
Amoxicillin-clavulanate |
Activity against major pathogens |
More costly |
|
Cephalosporins |
|
|
|
General |
Activity against major pathogens |
Alternative to beta-lactam agents and generally as
effective |
|
Second Generation |
|
|
|
Cefaclor |
Can be destroyed by Haemophilus influenzae and Moraxella
catarrhalis enzymes |
Associated with failure in patients with severe disease |
|
Cefprozil |
Moderate H. influenzae activity |
|
|
Cefuroxime |
|
|
|
Loracarbef |
Moderate H. influenzae activity |
|
|
Third Generation |
|
|
|
Cefdinir |
|
|
|
Cefibuten |
No activity against Staphylococcus aureus |
Poor gram-positive activity limits use |
|
Cefixime |
Poor activity against S. aureus |
|
|
Cefpodoxime |
|
|
|
Macrolides |
|
Active
against Mycobacterium avium. M. kansaii |
|
General |
Macrolide resistance concerning with S. pneumoniae
|
|
|
Azithromycin |
Greatest activity against H. influenzae |
Short course of 3-5 days may be used. Long term may cause hearing loss. |
|
Clarithromycin |
Greatest activity against S. pneumoniae |
Alteration of taste may be an issue with bid dosing |
|
Erythromycin |
Poor activity against H. influenzae |
Limited spectrum of activity |
|
Tetracyclines |
|
|
|
Doxycycline |
Covers major pathogens and atypical organisms S. pneumoniae
resistance is common |
Maybe an alternative to quinolones and macrolides when
atypical coverage is needed. See PMID: 21977068 |
|
Minocycline |
Similar to doxycycline |
|
|
Tetracycline |
Limited activity against major pathogens |
Limited spectrum of activity |
|
Fluoroquinolones |
|
|
|
General |
Active against all major pathogens, atypical pathogens, Enterobacteriaceae,
and Pseudomonas aeruginosa |
|
|
Ciprofloxacin |
Least active against S. pneumoniae |
Use if P. aeruginosa coverage is required |
|
Gatifloxacin |
Enhanced gram-positive activity |
|
|
Levofloxacin |
|
|
|
Moxifloxacin |
Greatest activity against S. pneumoniae |
|
|
Other |
|
|
|
Trimethoprim-sulfamethoxazole |
Covers major pathogens |
Resistance limits use |
References:
“The properties that determine the anti-infective action of lipids are related to their structure, e.g., monoglycerides, free fatty acids. The monoglycerides are active; diglycerides and triglycerides are inactive. Of the saturated fatty acids, lauric acid(C-12) has greater antiviral activity than caprylic acid (C-8), capric acid (C-10) or myristic acid (C-14). In general, it is reported that the fatty acids and monoglycerides produce their killing/inactivating effect by lysing the plasma membrane lipid bilayer. The antiviral action attributed to monolaurin is that of solubilising the lipids and phospholipids in the envelope of the virus, causing the disintegration of the virus envelope. However, there is evidence from recent studies that one antimicrobial effect in bacteria is related to monolaurin's interference with signal transduction (Projan et al., 1994), and another antimicrobial effect in viruses is due to lauric acid's interference with virus assembly and viral maturation (Hornung et al., 1994).”
Dr Frederick Klenner: (1953) Early Clinical Usage of Vitamin C. Quote:
“Our interest with vitamin C against the virus organism began ten years ago in a modest rural home. Here a patient who was receiving symptomatic treatment for virus pneumonia had suddenly developed cyanosis. He refused hospitalization for supportive oxygen therapy. X-Ray had been considered because of its dubious value and because the nearest department equipped to give such treatment was 69 miles distant. Two grams of vitamin C was given intramuscularly with the hope that the anaerobic condition existing in the tissues would be relieved by the catalytic action of vitamin C acting as a gas transport aid in cellular respiration. This was an old idea; the important factor being that it worked. Within 30 minutes after giving the drug (which was carried in my medical bag for the treatment of diarrhea in children) the characteristic breathing and slate-like color had cleared. Returning six hours later, at eight in the evening, the patient was found sitting over the edge of his bed enjoying a late dinner. Strangely enough his fever was three degrees less than it was at 2 P.M. that same afternoon. This sudden change in the condition of the patient led us to suspect that vitamin C was playing a role of far greater significance than that of a simple respiratory catalyst. A second injection of one gram of vitamin C was administered, by the same route, on this visit and then subsequently at six hour intervals for the next three days. This patient was clinically well after 36 hours of chemotherapy. From this casual observation we have been able to assemble sufficient clinical evidence that prove unequivocally that vitamin C is the antibiotic of choice in the handling of all types of virus diseases. Furthermore it is a major adjuvant in the treatment of at other infectious diseases.
“This experimental “strike” on vitamin C as an antibiotic opened a new avenue of approach to the problem of dealing with the virus bodies. With a great deal of enthusiasm we decided to try its effectiveness with all of the childhood diseases. Measles was singled out more so than the others because of the knowledge that it was a small virus like the one causing poliomyelitis. It was reasonable to assume that if measles could be controlled then Poliomyelitis, too, would have a drug that could prevent as well as cure the disease. The use of vitamin C in measles proved to be medical curiosity. For the first time a virus infection could be handled as if it were a dog on a leash. In the Spring of 1948 measles was running in epidemic proportions in this section of the country. Our first act, then, was to have our own little daughters play with children known to be in the “contagious phase.” When the syndrome of fever redness of the eyes and throat, catarrh, spasmodic bronchial cough and Koplik spots had developed and the children were obviously sick, vitamin C was started.
“In this experiment it was found that 1000mg every four hours, by mouth, would modify the attack. Smaller doses allowed the disease to progress. When 1000mg was given every two hours all evidence of the infection cleared in 48 hours. If the drug was then discontinued for a similar period (48 hours) the above syndrome returned. We observed this of and on picture for thirty days at which time the drug (vitamin C) was given 1000 mg every 2 hours around the clock for four days. This time the picture cleared and did not return. These little girls did not develop the measles rash during the above experiment and although exposed many times since still maintain this “immunity.” Late cases were given the vitamin by needle. The results proved to be even more dramatic. Given by injection the same complete control of the measles syndrome was in evidence a 24 and 36 hour periods, depending entirely on the amount employed and the frequency of the administration. Aborting of these cases before the development of the rash apparently gives no interference to the development of immunity. Recent progress on the rapidity of growth (a development) of the virus bodies by means of the electronic microscope makes intelligent the failure experienced by earlier workers when employing vitamin C on the virus organism (or bodies). Unless the virus is completely destroyed, as demonstrated in the experiments with the virus using measles, the infection will again manifest itself after a short incubation period. Small, single daily doses do not even modify the course of the infection.”
Note Recent PubMed article states: “The blood half life of vitamin C is 30 minutes” with no intake.
More Klenner on Nutrition:
Also see: http://www.townsendletter.com/Klenner/KlennerProtocol_forMS.pdf Multiple sclerosis and myasthenia gravis recovery nutritional guidelines for vitamin dependencies where a much higher than normal dosage is therapeutic if given over a long enough time of several years.