How Much Vitamin C?   Well vs. Sick

© Dr. Katherine and Karl Poehlmann 2007, revised January 2013


Note: The following information is the product of medical research and not intended to be prescriptive. Please consult your health provider regarding vitamins and supplements pertaining to your specific condition. See for more free health information.


Since AA is so dynamic in its functions, there is no upper limit to the amount that has been reported used by many practitioner sources. The therapeutic failures of AA in high and low amounts have always been from not enough AA administered or from stopping intake too soon while more antioxidant action is needed by the patient. Stopping too soon too low can lead to symptoms of allergy. Dr. Klenner was able to test for the presence of antioxidant AA in the urine, and with high levels of intake did not see any antioxidant AA until the crisis was over and recovery was well established. This proved that all of the high amounts were converted to DHA, until enough AA was input to oxidize all the many grams of toxins.


Vitamin C is ascorbic acid, readily available in tablet, liquid, and powder form. Ascorbate is buffered ascorbic acid (calcium or sodium ascorbate)  which may be dissolved in sterile water designed for intravenous/injection use in high doses to combat chronic and acute illnesses.  Ester C is calcium ascorbate available in pill form. Calcium and sodium ascorbate is available in powder form. 


Liposomal AA (vitamin C) is nano-encapsulated in a phospholipid (lecithin) spherical envelope. It’s pharmacokinetics are more like the lipid vitamins. (CoQ10 and vitamin E) Its active persistence is much longer than water soluble AA. Its transfer gut-to-blood and blood-to-brain and blood-to-liver is over 90% compared to the nominal estimated 15% transfer gut to blood. This is nearly 5 times better.  Lipid coating insures delivery to lipid walled cells and microbes, both bacteria and viruses. There L-AA delivers its payload, ascorbic acid, that (when oxidized) converts to DHA (an oxidant), which kills microbes and infected immune and epithelial cells. 


Dr Levy has stated that oral L-AA (on a per gram of AA basis) is as effective as 8 to 10 times more IV sodium ascorbate. One gram = ~ 10 grams IV. This is acting against microbes. This means oral L-AA can be used in place of IV AA, at decreased costs and increased convenience. L-AA is available on  For toxin removal and instant poison neutralization, massive amounts of sodium Ascorbate IV are the best treatment, because the AA acts molecule for molecule against toxins, oxides and venoms.  It is best to combine high AA oral intake with both IV and L-AA administration, because both work in different ways and they complement each other in their actions.


Because sugar blocks AA, fruit juices are a poor way to get AA benefits. AA is best taken between meals and when a lot is needed, it can be taken every 1 to 4 hours. Small amounts, taken more frequently, works better than large doses, less frequently.


Cathcart has published a procedure for preparing ascorbate solution along with sources that sell the formulated solution. Dr. Klenner has published papers on the use of sodium ascorbate solution to provide IV and injected forms that permit very large therapeutic dosages which are necessary in treating life-threatening conditions.


We have additional data under Ongoing Research on our website

Vitamin C (Ascorbic Acid) IV Treatment Protocols for Cancer  (Oct 2011)

PubMed Abstracts Ascorbic Acid PharmacoKinetics:  (Nov 2011)

Vitamin C PharmacoKinetics and PharmacoDynamics:  (Nov 2011)

Ascorbic Acid Ketonic Multi-factor Protocols (January 2013)

How Vitamin C Works  (January 2013)

Liposomal Vitamin C  (January 2013)


Suggested amounts of Vitamin C (AA): [water soluble forms]

Based on blood concentration AA’s Half-Lifetime is 30 minutes; after 3 hours, depletion is to (1/2)6 = 1/64.


When well, more than 2 grams of oral AA at a time has lower uptake (gut to blood) effective percentages than for AA at lower dosages.  Water-soluble AA is estimated at ~i5% and Liposomal AA is estimated at 92% to 98% uptake efficiency.  Cathcart has shown that when you are sick, your water-soluble AA intake is much higher than 15%. See Titration to Bowel Tolerance.  Frequent, several gram dosages are called for See Cathcart’s Table, below


Well:  6 to 17 grams per day for a 200 lb. person. Take about 2 to 6 grams with every meal or up to 3 grams 6 times per day. Between meals is better. Sugar blocks AA action and cellular uptake.

Six grams per day minimum to start immune system’s T- and B- cells’ recovery of function. These are the white blood cells. Build up slowly by 500 mg tablets (1/2 gram) to bowel tolerance. If diarrhea occurs, decrease by 500 mg. This is your individual tolerance. Spread the dose over the day for maximum benefit.

A typical daily vitamin contains only 50-100 mg of vitamin C. This is 1/20th to 1/10th gram, just enough to prevent scurvy but not nearly enough to prevent infections and other illnesses.

 The best form of vitamin C is the one most readily absorbed. Usually this is buffered powder (e.g., Ester C) or liquid to place under the tongue or in juice.


Acute: Toxin/venom Poisoning: 

Up to 100 grams per hour 3 to 8 times per day.  Intra-Muscular and Intra-Venous solution (for shock and IV for unconsciousness)


Chronic: Fibromyalgia, Chronic Fatigue Syndrome, Lyme Disease, etc Minimum threshold for 100Kg body weight is about 6 grams. Frequency is several times per day. See below.

Depends on the condition, see Dr. Cathcart’s table on reverse side of this handout.


Ascorbate (AA) Dosage levels

Acute Illness: Oral dosage to bowel tolerance level depending of severity of illness, per Dr. Cathcart’s table. Severe colds may need 30 to 100 grams/day. Very few doctors prescribe Ascorbate effectively.


 2 tablespoons Vitamin C powder/hour for two days to several weeks, then decrease gradually. Quitting abruptly may result in “induced scurvy” condition. Vitamin C potentiates antibiotics, reduces allergic reaction to their use, and stops bacteria spread.


Chronic Illness: Polymicrobial infections may need 6, 12, 18, 24, or 32 grams per day of Vitamin C, with dosages evenly spaced (every 2, 3 or 4 hrs). Timed release tablets are worse than spaced dosage. Duration of use of Ascorbate for serious chronic intracellular infection and cancer may be forever.

Dr. Cathcart’s Table of Vitamin C Dosage

Dose Interval = 24 Hours/ # of Doses.

Source: Dr. Cathcart’s research at






4 – 15

4 – 6

Environ/food allergy

0.5 – 50

4 – 8

Anxiety, mild stress

15 – 25

4 – 6

Mild cold

30 – 60

6 – 10

Severe cold

60 – 100+

8 – 15


100 – 150

8 – 20

Coxsackie virus

100 – 150

8 – 20

Mononucleosis EBV

150 – 200+

12 – 25

Viral pneumonia

100 – 200+

12 – 25

Hay fever, asthma

15 – 50

4 – 8


25 – 150+

6 – 20


15 – 100

4 – 15

Ankylosing spondylitis

15 – 100

4 – 15

Reiter's syndrome

15 – 60

4 – 10

Acute anterior uveitis

30 – 100

4 – 15

Rheumatoid arthritis

15 – 100

4 – 15

Bacterial infections

30 – 200+

10 – 25

Infectious hepatitis

30 – 100

6 – 15

Candidiasis Yeast

15 – 200+

6 – 25

Highest levels require IV administration.  This is a guide. You should seek Professional Medical Support to administer high levels of AA by injection or IV.  Check the web for doctors in your community.  Look for orthomolecular and nutrition oriented doctors.

Other References:

  1. L. Pauling:  Lysine/Ascorbate-Related Amelioration of Angina (Arterial Sclerosis)  [JOM 1991] A remarkable Case History Antibiotics vs. Chlamydia pneumonia might be added to protocol The above article is found at this website on the Wayback Machine archives.
  2.  Linus Pauling: The [In-]Effectiveness of the National Cancer Institute [1977, After $billions, Still no AA studies]
  3. Massive Doses of Ascorbate: A Paradigm Shift  --- Robert F. Cathcart, M.D. (Sept 2000)



Also see Dr. Klenner’s articles:

 The Use of Vitamin C as an Antibiotic


 The Treatment of Poliomyelitis and Other Virus Diseases with Vitamin C


Observations On the Dose and Administration of Ascorbic Acid When Employed Beyond the Range Of A Vitamin In Human Pathology  -1971





Dr. Atkins’ Vita-Nutrient Solution: Nature’s Answer to Drugs   by Robert Atkins, M.D. Simon and Schuster, 1998, 1999, 407 pages. 

Dr. Atkins has compiled a guide to nutrition for the person who is ill. 


Vitamin C the Common Cold and the Flu  by Linus Pauling, Nobel Prize in Chemistry 1976, Freeman, 230 Pages.

A classic collection of information about how the body benefits from ascorbic acid (Vitamin C) when various diseases and infections are present. 


The Vitamin C Connection: Getting Well with Vitamin C  by Cheraskin, Ringsdorf, and Sisley, Harper  & Row, 1983, 291 pages. 

An update on Linus Pauling’s work, confirming his thesis and providing scientific research that connects Vitamin C to the prevention and treatment of colds, cancer, glaucoma, periodontal disease, pain, fatigue, allergy, rashes, vulnerability to stress, etc.


Cellular Health Series: Cancer  by Matthias Rath, MD, MR Publishing 80 pages with illustrated supplemental insert: The Victory Over Cancer is at Hand. Microbes invade the host’s leukocytes (macrophages) and/or other (liver, tissue, etc. cells), take over intracellular gene-driven enzyme production, and produce an imbalance. The insert describes how a combination of L-lysine, L-proline, Vitamin C and Epigallocatechin Gallate (EGCG, derived from tea or green tea extract) stops the destruction of tissue by viral-infected cancer cells. L-lysine is known to facilitate healing of Herpes-caused lesions. Vitamin C also facilitates healing, and disables viral and bacterial spreading-factor enzymes.


Irwin Stone’s Book  The Healing Factor online at the Vitamin C Foundation Website.


Tomas Levy MD, JD  Curing the Incurable at lookup Chapter 3 Toxins





Dr. Poehlmann is the author of two books on chronic infections:  Rheumatoid Arthritis: The Infection Connection (2002) and  Arthritis and Autoimmune Disease: The Infection Connection , available at



Copyright KF and KM Poehlmann, January 2013, all rights reserved.

Our Experience and Qualifications

(Katherine Poehlmann, PhD and Karl Poehlmann)

Inflammation, chronic infections, nutrition and immunity are topics we have researched broadly in our studies of worldwide medical knowledge, documented on the Internet and in the historical archives of medicine.  We have spent over ten calendar years reading about these inter-related subjects, attending postgraduate medical conferences. We have read countless medical texts, abstracts, and papers, online in the National Library of Medicine and contained at various authoritative medical, nutritional and biological websites. The mass of the available information worldwide is tremendous. Search engines can reach much of it, so it can be correlated productively.



Nothing herein or referenced herein should be considered prescriptive for any medical condition.  This information is for study and education purposes only.  The readers are advised to find and consult well-educated, trained and licensed medical and nutritional practitioners who shall evaluate the many circumstances and conditions of each of their patients and will devise appropriate treatments and nutritional plans for them.  It is recognized that each person has the right and duty to be well informed about the best foods, nutrition and medical practices available that will promote their own good health.  The opinions expressed herein are those of the author(s) and the sources cited and there are many divergences of opinions on many topics. The readers must resolve the conflicts, in their own minds, after careful consideration of all the details and after any further necessary research and study.


Our books are available on  

More intermediate-level information is pointed to below, See Latest Findings and Free Articles.

Rheumatoid Arthritis: The Infection Connection  (2001, and 2011) and

Arthritis and Autoimmune Disease: The Infection Connection (2012)


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